Homologous recombination (HR) is an evolutionarily conserved process that plays a pivotal
role in the equilibrium between genetic stability and diversity. HR is commonly considered to …

Pathogenic microorganisms employ numerous molecular strategies in order to delay or
circumvent recognition by the immune system of their host. One of the most widely used …

Trypanosoma brucei evades the adaptive immune response through the expression of
antigenically distinct Variant Surface Glycoprotein (VSG) coats. To understand the …

A main determinant of prolonged Trypanosoma brucei infection and transmission and
success of the parasite is the interplay between host acquired immunity and antigenic …

Background Trypanosoma brucei, the causative agent of African slee** sickness,
undergoes a complex developmental cycle that takes place in mammalian and insect hosts …

African trypanosomes are single-celled protozoan parasites that are capable of long-term
survival while living extracellularly in the bloodstream and tissues of mammalian hosts …

One of the most powerful drivers of evolutionary change is the process of adaptation and
counter‐adaptation by interacting species (1). The so‐called “arms race” between parasites …

Eukaryotic microorganisms have evolved ingenious mechanisms to generate variability at
their cell surface, permitting differential adherence, rapid adaptation to changing …

Homologous recombination (HR) mediates one of the major mechanisms of trypanosome
antigenic variation by placing a different variant surface glycoprotein (VSG) gene under the …

The African trypanosome Trypanosoma brucei is a flagellated unicellular parasite
transmitted by tsetse flies that causes African slee** sickness in sub-Saharan Africa …