The 3D architecture of tissues bearing tumors impacts on the mechanical microenvironment
of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic …

Simple Summary Non-melanoma skin cancer (NMSC) is the main type of cancer in the
Caucasian population, and the number of cases continues to rise. Research mostly focuses …

The gut barrier acts as a first line of defense in the body, and plays a vital role in nutrition
and immunoregulation. A layer of epithelial cells bound together via intercellular junction …

Although the age of the genome gave us much insight about how our organs fail with
disease, it also suggested that diseases do not arise from mutations alone; rather, they …

Cell extrusion is a universal mode of cell removal from tissues, and it plays an important role
in regulating cell numbers and eliminating unwanted cells. However, the underlying …

Mutations in RAS are key oncogenic drivers and therapeutic targets. Oncogenic Ras
proteins activate a network of downstream signalling pathways, including extracellular …

Tissue-intrinsic defense mechanisms eliminate aberrant cells from epithelia and thereby
maintain the health of develo** tissues or adult organisms.'Interface …

Neoplastic cells of non-immunogenic pancreatic ductal adenocarcinoma (PDAC) express
indoleamine 2, 3-dioxygenase 1 (IDO-1), an immunosuppressive enzyme. The metabolites …

Simple Summary Cholesterol and cholesterol derivatives accumulate in prostate cancer
cells. Epidemiologic studies about diet and/or treatment with cholesterol-lowering drugs …

Xenopus embryos are covered with a complex epithelium containing numerous multiciliated
cells (MCCs). During late-stage development, there is a dramatic remodeling of the …