[HTML][HTML] Cellular senescence in lung cancer: molecular mechanisms and therapeutic interventions

SK Jha, G De Rubis, SR Devkota, Y Zhang… - Ageing research …, 2024 - Elsevier
Lung cancer stands as the primary contributor to cancer-related fatalities worldwide,
affecting both genders. Two primary types exist where non-small cell lung cancer (NSCLC) …

Metronomic chemotherapy and drug repurposing: A paradigm shift in oncology

N Jan, S Sofi, H Qayoom, A Shabir, BU Haq, MA Macha… - Heliyon, 2024 - cell.com
Cancer represents a significant global health and economic burden due to its high mortality
rates. While effective in some instances, traditional chemotherapy often falls short of entirely …

Emerging role of tumor suppressing microRNAs as therapeutics in managing non-small cell lung cancer

S Singh, S Saxena, H Sharma, KR Paudel… - … -Research and Practice, 2024 - Elsevier
Lung cancer (LC) is the second leading cause of death across the globe after breast cancer.
There are two types of LC viz. small cell lung cancer (SCLC) and non-small cell lung cancer …

Involvement of osteopontin, EpCAM, estrogen receptor-alpha, and carbonic anhydrase IX protein in managing lung cancer via Berberine-loaded liquid crystalline …

G De Rubis, KR Paudel, VSRR Allam, V Malyla… - … -Research and Practice, 2024 - Elsevier
Lung cancer is the second most common type of cancer globally, with about 2.2 million lung
cancer cases diagnosed in 2020, which lead to 1.7 million deaths worldwide [1] …

Targeting the mitochondria in chronic respiratory diseases

DK Chellappan, KR Paudel, NW Tan, KS Cheong… - Mitochondrion, 2022 - Elsevier
Mitochondria are one of the basic essential components for eukaryotic life survival. It is also
the source of respiratory ATP. Recently published studies have demonstrated that …

18-β-Glycyrrhetinic acid encapsulated PLGA nanoparticles attenuate lung cancer proliferation and migration

KR Paudel, MSB Mohamad, G De Rubis… - Journal of Drug Delivery …, 2024 - Elsevier
Conventional treatment methods to treat lung cancer include radiation therapy,
chemotherapy, and immunotherapy. However, they cause severe adverse effects and …

[HTML][HTML] Evaluation of the cytotoxic activity and anti-migratory effect of berberine–phytantriol liquid crystalline nanoparticle formulation on non-small-cell lung cancer in …

AM Alnuqaydan, AG Almutary, M Azam, B Manandhar… - Pharmaceutics, 2022 - mdpi.com
Non-small-cell lung cancer (NSCLC) is the most common form of lung cancer, which is a
leading cause of cancer-related deaths worldwide. Berberine is an isoquinoline alkaloid that …

Cigarette smoking induces lung cancer tumorigenesis via upregulation of the WNT/β-catenin signaling pathway

V Malyla, KR Paudel, G De Rubis, NG Hansbro… - Life Sciences, 2023 - Elsevier
Lung cancer has the highest mortality rate compared to any other cancer worldwide, and
cigarette smoking is one of the major etiological factors. How cigarette smoke (CS) induces …

Anticancer activity of NFκB decoy oligonucleotide-loaded nanoparticles against human lung cancer

VK Kannaujiya, G De Rubis, KR Paudel… - Journal of Drug Delivery …, 2023 - Elsevier
Non-small cell lung cancer (NSCLC) is among the leading global causes of cancer-related
mortality. Current treatment options have limited efficacy and severe adverse effects …

Nanoformulations-based metronomic chemotherapy: mechanism, challenges, recent advances, and future perspectives

VK Panthi, K Dua, SK Singh, G Gupta, PM Hansbro… - Pharmaceutics, 2023 - mdpi.com
Cancer-related death is a significant health and economic burden worldwide, and some
conventional chemotherapy is associated with limited effectiveness in completely curing …