Microbiota medicine: towards clinical revolution

P Gebrayel, C Nicco, S Al Khodor, J Bilinski… - Journal of translational …, 2022 - Springer
The human gastrointestinal tract is inhabited by the largest microbial community within the
human body consisting of trillions of microbes called gut microbiota. The normal flora is the …

Hyaluronan: molecular size‐dependent signaling and biological functions in inflammation and cancer

AG Tavianatou, I Caon, M Franchi… - The FEBS …, 2019 - Wiley Online Library
Hyaluronan (HA) is a linear nonsulfated glycosaminoglycan of the extracellular matrix that
plays a pivotal role in a variety of biological processes. High‐molecular weight HA exhibits …

Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics

NK Karamanos, Z Piperigkou, AD Theocharis… - Chemical …, 2018 - ACS Publications
The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …

Glutamatergic signaling along the microbiota-gut-brain axis

A Baj, E Moro, M Bistoletti, V Orlandi, F Crema… - International journal of …, 2019 - mdpi.com
A complex bidirectional communication system exists between the gastrointestinal tract and
the brain. Initially termed the “gut-brain axis” it is now renamed the “microbiota-gut-brain …

Tryptophan metabolites along the microbiota-gut-brain axis: an interkingdom communication system influencing the gut in health and disease

A Bosi, D Banfi, M Bistoletti… - International Journal of …, 2020 - journals.sagepub.com
The 'microbiota-gut-brain axis' plays a fundamental role in maintaining host homeostasis,
and different immune, hormonal, and neuronal signals participate to this interkingdom …

Revisiting the hallmarks of cancer: The role of hyaluronan

I Caon, B Bartolini, A Parnigoni, E Caravà… - Seminars in cancer …, 2020 - Elsevier
Extracellular matrix (ECM) is a complex network of macromolecules such as proteoglycans
(PGs), glycosaminoglycans (GAGs) and fibrous proteins present within all tissues and …

Inflammation, extracellular matrix remodeling, and proteostasis in tumor microenvironment

M Marozzi, A Parnigoni, A Negri, M Viola… - International journal of …, 2021 - mdpi.com
Cancer is a multifaceted and complex pathology characterized by uncontrolled cell
proliferation and decreased apoptosis. Most cancers are recognized by an inflammatory …

Impact of microbial metabolites on microbiota–gut–brain axis in inflammatory bowel disease

D Banfi, E Moro, A Bosi, M Bistoletti… - International journal of …, 2021 - mdpi.com
The complex bidirectional communication system existing between the gastrointestinal tract
and the brain initially termed the “gut–brain axis” and renamed the “microbiota–gut–brain …

The complex interplay between extracellular matrix and cells in tissues

D Manou, I Caon, P Bouris, IE Triantaphyllidou… - The extracellular matrix …, 2019 - Springer
Extracellular matrix (ECM) maintains the structural integrity of tissues and regulates cell and
tissue functions. ECM is comprised of fibrillar proteins, proteoglycans (PGs) …

Cell energy metabolism and hyaluronan synthesis

I Caon, A Parnigoni, M Viola… - … of Histochemistry & …, 2021 - journals.sagepub.com
Hyaluronan (HA) is a linear glycosaminoglycan (GAG) of extracellular matrix (ECM)
synthesized by three hyaluronan synthases (HASes) at the plasma membrane using uridine …