Control of polymeric nanoparticle size to improve therapeutic delivery

JW Hickey, JL Santos, JM Williford, HQ Mao - Journal of Controlled …, 2015 - Elsevier
As nanoparticle (NP)-mediated drug delivery research continues to expand, understanding
parameters that govern NP interactions with the biological environment becomes …

Nanosuspensions of poorly water-soluble drugs prepared by bottom-up technologies

J Du, X Li, H Zhao, Y Zhou, L Wang, S Tian… - International journal of …, 2015 - Elsevier
In recent years, nanosuspension has been considered effective in the delivery of water-
soluble drugs. One of the main challenges to effective drug delivery is designing an …

Self-assembling process of flash nanoprecipitation in a multi-inlet vortex mixer to produce drug-loaded polymeric nanoparticles

H Shen, S Hong, RK Prud'homme, Y Liu - Journal of Nanoparticle …, 2011 - Springer
We present an experimental study of self-assembled polymeric nanoparticles in the process
of flash nanoprecipitation using a multi-inlet vortex mixer (MIVM). β-Carotene and …

Flash nanocomplexation (FNC): A new microvolume mixing method for nanomedicine formulation

K Li, Y Wang, Y Xu, G Shi, S Wei, X Zhang… - Chinese Chemical …, 2024 - Elsevier
The application of nanotechnologies in formulation has significantly promoted the
development of modern medical and pharmacological science, especially for nanoparticle …

Enhanced dissolution of inhalable cyclosporine nano-matrix particles with mannitol as matrix former

K Yamasaki, PCL Kwok, K Fukushige… - International journal of …, 2011 - Elsevier
This study aims to improve the dissolution of inhalable cyclosporine A nanoparticles by
formulating the drug with mannitol as a hydrophilic nano-matrix former. The effect of …

Morphology tuning of aggregation-induced emission probes by flash nanoprecipitation: shape and size effects on in vivo imaging

M Wang, Y Xu, Y Liu, K Gu, J Tan, P Shi… - … applied materials & …, 2018 - ACS Publications
Aggregation-induced emission (AIE) imaging probes have recently received considerable
attention because of their unique property of high performance in the aggregated state and …

Core–shell structure and aggregation number of micelles composed of amphiphilic block copolymers and amphiphilic heterografted polymer brushes determined by …

M Szymusiak, J Kalkowski, H Luo, AJ Donovan… - ACS macro …, 2017 - ACS Publications
A large group of functional nanomaterials employed in biomedical applications, including
targeted drug delivery, relies on amphiphilic polymers to encapsulate therapeutic payloads …

A comparison of implicit-and explicit-solvent simulations of self-assembly in block copolymer and solute systems

JR Spaeth, IG Kevrekidis… - The Journal of chemical …, 2011 - pubs.aip.org
We have developed explicit-and implicit-solvent models for the flash nanoprecipitation
process, which involves rapid coprecipitation of block copolymers and solutes by changing …

Large-scale synthesis of lipid–polymer hybrid nanoparticles using a multi-inlet vortex reactor

RH Fang, KNH Chen, S Aryal, CMJ Hu, K Zhang… - Langmuir, 2012 - ACS Publications
Lipid–polymer hybrid nanoparticles combine the advantages of both polymeric and
liposomal drug carriers and have shown great promise as a controlled drug delivery …

Facile preparation of AIE-active fluorescent nanoparticles through flash nanoprecipitation

M Wang, N Yang, Z Guo, K Gu, A Shao… - Industrial & …, 2015 - ACS Publications
Flash nanoprecipitation (FNP) is an easily scalable and fast processing method for the
preparation of nanoparticles (NPs) with simple vortex equipment. By using the FNP method …