Aminoacyl-tRNA synthetases (ARSs) are essential enzymes for protein synthesis with
evolutionarily conserved enzymatic mechanisms. Despite their similarity across organisms …

Our understanding of gene expression has changed dramatically over the past decade,
largely catalysed by technological developments. High-throughput experiments …

We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations.
Phosphoproteome data elucidated signaling pathways associated with somatic mutations …

Saliva is a noninvasive biofluid that can contain metabolite signatures of oral squamous cell
carcinoma (OSCC). Conductive polymer spray ionization mass spectrometry (CPSI-MS) is …

Aminoacyl‐tRNA synthetases (ARSs) are essential and ubiquitous 'house‐kee**'enzymes
responsible for charging amino acids to their cognate tRNAs and providing the substrates for …

Proofreading (editing) of mischarged tRNAs by cytoplasmic aminoacyl-tRNA synthetases
(aaRSs), whose impairment causes neurodegeneration and cardiac diseases, is of high …

Dysfunctions in mitochondria–the powerhouses of the cell–lead to several human
pathologies. Because mitochondria integrate nuclear and mitochondrial genetic systems …

Although key tumorigenic and tumor-suppressive factors have been unveiled over the last
several decades, cancer remains the most life-threatening disease. Multiomic analyses of …

Pathological mutations in tRNA genes and tRNA processing enzymes are numerous and
result in very complicated clinical phenotypes. Mitochondrial tRNA (mt-tRNA) genes are …

Breast cancer is the most common female cancer, affecting approximately one in eight
women during their life-time. Besides environmental triggers and hormones, inherited …