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Accelerating antiviral drug discovery: lessons from COVID-19
During the coronavirus disease 2019 (COVID-19) pandemic, a wave of rapid and
collaborative drug discovery efforts took place in academia and industry, culminating in …
collaborative drug discovery efforts took place in academia and industry, culminating in …
Antiviral approaches against influenza virus
Preventing and controlling influenza virus infection remains a global public health
challenge, as it causes seasonal epidemics to unexpected pandemics. These infections are …
challenge, as it causes seasonal epidemics to unexpected pandemics. These infections are …
[HTML][HTML] TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry
SARS-CoV-2 is associated with broad tissue tropism, a characteristic often determined by
the availability of entry receptors on host cells. Here, we show that TMEM106B, a lysosomal …
the availability of entry receptors on host cells. Here, we show that TMEM106B, a lysosomal …
Synergistic effects between metal nanoparticles and commercial antimicrobial agents: A review
Nanotechnology has expanded into a broad range of clinical applications. In particular,
metal nanoparticles (MNPs) display unique antimicrobial properties, a fundamental function …
metal nanoparticles (MNPs) display unique antimicrobial properties, a fundamental function …
Antiviral drug discovery: preparing for the next pandemic
Clinically approved antiviral drugs are currently available for only 10 of the more than 220
viruses known to infect humans. The SARS-CoV-2 outbreak has exposed the critical need …
viruses known to infect humans. The SARS-CoV-2 outbreak has exposed the critical need …
Baricitinib: a review of pharmacology, safety, and emerging clinical experience in COVID‐19
A hyperinflammatory response to severe acute respiratory syndrome‐coronavirus 2 (SARS‐
CoV‐2) infection, reminiscent of cytokine release syndrome, has been implicated in the …
CoV‐2) infection, reminiscent of cytokine release syndrome, has been implicated in the …
Evolution of SARS-CoV-2 variants: implications on immune escape, vaccination, therapeutic and diagnostic strategies
The COVID-19 pandemic caused by SARS-CoV-2 is associated with a lower fatality rate
than its SARS and MERS counterparts. However, the rapid evolution of SARS-CoV-2 has …
than its SARS and MERS counterparts. However, the rapid evolution of SARS-CoV-2 has …
Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses
Y Ma, E Frutos-Beltrán, D Kang… - Chemical Society …, 2021 - pubs.rsc.org
During the last forty years we have witnessed impressive advances in the field of antiviral
drug discovery culminating with the introduction of therapies able to stop human …
drug discovery culminating with the introduction of therapies able to stop human …
Antiviral strategies targeting host factors and mechanisms obliging+ ssRNA viral pathogens
The ongoing COVID-19 pandemic, periodic recurrence of viral infections, and the
emergence of challenging variants has created an urgent need of alternative therapeutic …
emergence of challenging variants has created an urgent need of alternative therapeutic …
Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets
Abstract Influenza A Virus (IAV) is a recurring respiratory virus with limited availability of
antiviral therapies. Understanding host proteins essential for IAV infection can identify …
antiviral therapies. Understanding host proteins essential for IAV infection can identify …