The World Health Organization (WHO) has recognized obesity as one of the top ten threats
to human health. It is estimated that the number of obese and overweight people worldwide …

The growing worldwide burden of insulin resistance (IR) emphasizes the importance of early
identification for improved management. Obesity, particularly visceral obesity, has been a …

Skeletal muscle plays important roles in normal biological activities and whole-body energy
homeostasis in humans. The growth and development of skeletal muscle also directly …

The dysregulation of the β-cell functional mass, which is a reduction in the number of β-cells
and their ability to secure adequate insulin secretion, represents a key mechanistic factor …

Nicotinamide phosphoribosyltransferase (NAMPT) plays a central role in mammalian cell
metabolism by contributing to nicotinamide adenine dinucleotide biosynthesis. However …

Gymnema sylvestre (GS) and berberine (BBR) are natural products that have demonstrated
therapeutic potential for the management of obesity and its comorbidities, as effective and …

Background Type 1 diabetes is an autoimmune disease directed to the pancreatic islets
where inflammation leads to the death of insulin-producing ß cells and insulin deficiency …

Purpose This study aimed to evaluate the role of the extracellular part of insulin-regulated
aminopeptidase (IRAPe), interleukin (IL)-34, irisin, and visfatin in the development of insulin …

Background Epidemiological studies have suggested that adipsin and visfatin are
associated with the development of type 2 diabetes. This is the first study to investigate the …

Background and aim Diabetic retinopathy is a serious and common complication of diabetes
that causes irreversible blindness. The aim of the present study was to assess the …