There are multiple reasons why the next generation of biological and medical studies
require increasing numbers of samples. Biological systems are dynamic, and the effect of a …

The proteome, or collection of proteoforms expressed in a biological system, is dynamic and
heterogeneous. As our appreciation for the complexity of the proteome has evolved, so have …

We evaluate the quantitative performance of the newly released Asymmetric Track Lossless
(Astral) analyzer. Using data-independent acquisition, the Thermo Scientific Orbitrap Astral …

Single-cell proteomics by mass spectrometry is emerging as a powerful and unbiased
method for the characterization of biological heterogeneity. So far, it has been limited to …

A plethora of software suites and multiple classes of spectral libraries have been developed
to enhance the depth and robustness of data-independent acquisition (DIA) data …

Single‐cell proteomics aims to characterize biological function and heterogeneity at the
level of proteins in an unbiased manner. It is currently limited in proteomic depth, throughput …

Venous thromboembolism (VTE) comprising deep venous thrombosis and pulmonary
embolism is a major cause of morbidity and mortality. Short-term immobility-related …

Brain metastases (BMs) are the most common and among the deadliest brain tumors.
Currently, there are no reliable predictors of BM development from primary cancer, which …

Identifying pharmacological probes for human proteins represents a key opportunity to
accelerate the discovery of new therapeutics. High-content screening approaches to expand …

Owing to its roles in cellular signal transduction, protein phosphorylation plays critical roles
in myriad cell processes. That said, detecting and quantifying protein phosphorylation has …