Amyloid-β: a potential link between epilepsy and cognitive decline

M Romoli, A Sen, L Parnetti, P Calabresi… - Nature Reviews …, 2021 - nature.com
People with epilepsy—in particular, late-onset epilepsy of unknown aetiology—have an
elevated risk of dementia, and seizures have been detected in the early stages of Alzheimer …

[HTML][HTML] GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer's disease

J Jiménez-Balado, TS Eich - Seminars in cell & developmental biology, 2021 - Elsevier
In this review, we focus on the potential role of the γ-aminobutyric acidergic (GABAergic)
system in age-related episodic memory impairments in humans, with a particular focus on …

Clinical, imaging, and biomarker evidence of amyloid-and tau-related neurodegeneration in late-onset epilepsy of unknown etiology

LB Hickman, JM Stern, DHS Silverman… - Frontiers in …, 2023 - frontiersin.org
Accumulating evidence suggests amyloid and tau-related neurodegeneration may play a
role in development of late-onset epilepsy of unknown etiology (LOEU). In this article, we …

Post-stroke everything

A Lekoubou, C Nguyen, M Kwon, AD Nyalundja… - Current neurology and …, 2023 - Springer
Abstract Purpose of Review This review aims at providing updates on selected post-stroke
complications. We examined recent advances in diagnosing and treating the following post …

Epileptogenicity of white matter lesions in cerebral small vessel disease: a systematic review and meta-analysis

JI Doerrfuss, JM Hebel, M Holtkamp - Journal of neurology, 2023 - Springer
Background The epileptogenic properties of white matter lesions (WML) in cerebral small
vessel disease (CSVD) are not yet understood. The aim of our systematic review and meta …

[HTML][HTML] Late-onset epilepsy clinic: from clinical diagnostics to biomarkers

V Punia, S Bhansali, C Tsai - Seizure: European Journal of Epilepsy, 2024 - Elsevier
The unique patho-clinical entity of late-onset epilepsy (LOE), distinguished by its distinct
natural history, from its onset to the prognosis it portends, necessitates specialized care. We …

Mortality in patients with late-onset epilepsy: results from the atherosclerosis risk in communities study

EL Johnson, GL Krauss, A Kucharska-Newton, AD Lam… - Neurology, 2021 - neurology.org
Background and Objectives To determine the risk of mortality and causes of death in
persons with late-onset epilepsy (LOE) compared to those without epilepsy in a community …

Association between structural brain MRI abnormalities and epilepsy in older adults

JJ Gugger, AE Walter, R Diaz‐Arrastia… - Annals of Clinical …, 2024 - Wiley Online Library
Objective To determine the association between brain MRI abnormalities and incident
epilepsy in older adults. Methods Men and women (ages 45–64 years) from the …

Structural neuroimaging in adults and adolescents with newly diagnosed focal epilepsy: the human epilepsy project

AM Bank, R Kuzniecky, RC Knowlton, GD Cascino… - Neurology, 2022 - neurology.org
Background and Objectives Identification of an epileptogenic lesion on structural
neuroimaging in individuals with focal epilepsy is important for management and treatment …

Structural brain network deviations predict recovery after traumatic brain injury

JJ Gugger, N Sinha, Y Huang, AE Walter, C Lynch… - NeuroImage: Clinical, 2023 - Elsevier
Objective Traumatic brain injury results in diffuse axonal injury and the ensuing maladaptive
alterations in network function are associated with incomplete recovery and persistent …