Habituation to a novel environment in rodents is commonly defined as a change in
exploratory or locomotor activity over time (intrasession) or with repeated exposures …

In behavioral neurosciences, such as neurobiology and biopsychology, animal models
make it possible to investigate brain–behavior relations, with the aim of gaining insight into …

Mice are increasingly being used in behavioral neuroscience, largely replacing rats as the
behaviorist's animal of choice. Before aspects of behavior such as emotionality or cognition …

Transgenic Tg2576 mice overexpressing human amyloid precursor protein (hAPP) are a
widely used Alzheimer's disease (AD) mouse model to evaluate treatment effects on amyloid …

This protocol details a method for using a T-maze to assess the cognitive ability of rodents.
The T-maze is an elevated or enclosed apparatus in the form of a T placed horizontally …

Kondziela7 devised the inverted screen test and published it in 1964. It is a test of muscle
strength using all four limbs. Most normal mice easily score maximum on this task; it is a …

Light–dark box and open field are conventional tests for assessment of anxiety-like behavior
in the laboratory mice, based on approach–avoidance conflict. However, except the basic …

Patients with lupus (SLE) experience progressive cognitive loss without evidence of CNS
vascular disease or inflammation. SLE patients produce anti-DNA antibodies that crossreact …

The aim of the present study was to investigate the effects of individual housing on mouse
behavior. The male mice of the C57BL/6J and DBA/2 strains were separated at the age of 4 …

Subtle regional differences in microglial phenotype exist in the adult mouse brain. We
investigated whether these differences were amplified during ageing and following systemic …