Survival rates for most paediatric cancers have improved at a remarkable pace over the past
four decades. In developed countries, cure is now the probable outcome for most children …

Cisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide
range of pediatric and adult malignances. However, it has various side effects which limit its …

Background Cisplatin chemotherapy and surgery are effective treatments for children with
standard-risk hepatoblastoma but may cause considerable and irreversible hearing loss …

Cisplatin is one of the most widely-used drugs to treat cancers. However, its nephrotoxic and
ototoxic side-effects remain major clinical limitations. Recent studies have improved our …

Drug ototoxicity limits the quality of life of patients after treatment, having serious
consequences, especially for psychosocial development of children. Although the ototoxicity …

Purpose Cisplatin is widely used but highly ototoxic. Effects of cumulative cisplatin dose on
hearing loss have not been comprehensively evaluated in survivors of adult-onset cancer …

Background Sodium thiosulfate is an antioxidant shown in preclinical studies in animals to
prevent cisplatin-induced hearing loss with timed administration after cisplatin without …

Ototoxicity refers to damage of inner ear structures (ie, the cochlea and vestibule) and their
function (hearing and balance) following exposure to specific in-hospital medications (ie …

Cisplatin is currently one of the most widely-used chemotherapeutic agents against various
malignancies. Its clinical application is limited, however, by inherent renal and cardiac …

Platinum‐induced peripheral neurotoxicity (PIPN) is a common side effect of platinum‐
based chemotherapy that may cause dose reduction and discontinuation, with oxaliplatin …