Genome damage and transcription are intimately linked. Tens to hundreds of thousands of
DNA lesions arise in each cell each day, many of which can directly or indirectly impede …

The MYC protooncogene functions as a universal amplifier of transcription through
interaction with numerous factors and complexes that regulate almost every cellular process …

Although the MYC oncogene has been implicated in cancer, a systematic assessment of
alterations of MYC, related transcription factors, and co-regulatory proteins, forming the …

Genome instability is a hallmark of cancer, and DNA replication is the most vulnerable
cellular process that can lead to it. Any condition leading to high levels of DNA damage will …

The MYC proto-oncogene has been implicated in the pathogenesis of most types of human
tumors. MYC activation alone in many normal cells is restrained from causing tumorigenesis …

This review is intended to provide a broad outline of the biological and molecular functions
of MYC as well as of the larger protein network within which MYC operates. We present a …

The nucleolus is the major site for synthesis of ribosomes, complex molecular machines that
are responsible for protein synthesis. A wealth of research over the past 20 years has clearly …

Small-cell lung cancer (SCLC) has traditionally been considered a recalcitrant cancer with a
dismal prognosis, with only modest advances in therapeutic strategies over the past several …

The germinal center (GC) is a microanatomical compartment wherein high-affinity antibody-
producing B cells are selectively expanded. B cells proliferate and mutate their antibody …

Genomes undergo different types of sporadic alterations, including DNA damage, point
mutations, and genome rearrangements, that constitute the basis for evolution. However …