The influence of oviposition status on measures of transmission potential in malaria-infected mosquitoes depends on sugar availability

JC Shiau, N Garcia-Diaz, DE Kyle, AK Pathak - Parasites & Vectors, 2024 - Springer
Background Like other oviparous organisms, the gonotrophic cycle of mosquitoes is not
complete until they have selected a suitable habitat to oviposit. In addition to the …

[HTML][HTML] Development of peptoid-based heteroaryl-decorated histone deacetylase (HDAC) inhibitors with dual-stage antiplasmodial activity

D Stopper, LP de Carvalho, ML de Souza… - European Journal of …, 2024 - Elsevier
Dynamics of epigenetic modifications such as acetylation and deacetylation of histone
proteins have been shown to be crucial for the life cycle development and survival of …

[HTML][HTML] Blood meals from 'dead-end'vertebrate hosts enhance transmission potential of malaria-infected mosquitoes

AK Pathak, JC Shiau, RCS Freitas, DE Kyle - One Health, 2023 - Elsevier
Ingestion of an additional blood meal (s) by a hematophagic insect can accelerate
development of several vector-borne parasites and pathogens. Most studies, however, offer …

Screening the Global Health Priority Box against Plasmodium berghei liver stage parasites using an inexpensive luciferase detection protocol

GB Nguyen, CA Cooper, O McWhorter, R Sharma… - Malaria Journal, 2024 - Springer
Background Malaria, a disease caused by parasites of the genus Plasmodium, continues to
impact many regions globally. The rise in resistance to artemisinin-based anti-malarial drugs …

Killing of Plasmodium Sporozoites by Basic Amphipathic α-Helical Fusion Peptides

MC Aguirre-Botero, E Aliprandini, A Gladston, O Pacios… - Microorganisms, 2024 - mdpi.com
Membranolytic molecules constitute the first line of innate immune defense against
pathogenic microorganisms. Plasmodium sporozoites are potentially exposed to these …

A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites

SP Maher, MA Bakowski, A Vantaux, EL Flannery… - …, 2024 - pmc.ncbi.nlm.nih.gov
Radical cure of Plasmodium vivax malaria must include elimination of quiescent
'hypnozoite'forms in the liver; however, the only FDA-approved treatments are …

Blood meals from 'dead-end'vertebrate hosts enhance transmission potential of malaria-infected mosquitoes

AK Pathak, JC Shiau, CRS de Freitas, DE Kyle - bioRxiv, 2022 - biorxiv.org
Ingestion of an additional blood meal (s) by mosquitoes can accelerate parasite migration to
the salivary glands in infected mosquitoes. Most studies, however, offer blood from the same …

[PDF][PDF] The importance of the extrinsic incubation period for malaria transmission, surveillance and control

IJ Stopard - 2023 - core.ac.uk
The extrinsic incubation period (EIP) of malaria is the time required for Plasmodium
parasites to undergo sexual reproduction and asexual replication within the mosquito …

[HTML][HTML] Cryopreservation of Plasmodium Sporozoites

C Bowers, L Hancox, K Peissig, JC Shiau, A Vantaux… - Pathogens, 2022 - mdpi.com
Malaria is a deadly disease caused by the parasite, Plasmodium, and impacts the lives of
millions of people around the world. Following inoculation into mammalian hosts by infected …

Oviposition status and sugar availability influence measures of transmission potential in malaria-infected mosquitoes

JC Shiau, N Garcia-Diaz, DE Kyle, AK Pathak - bioRxiv, 2024 - biorxiv.org
Background Like other oviparous organisms, the gonotrophic cycle of mosquitoes is not
complete until they have selected a suitable habitat to oviposit. In addition to the …