Survivin is the smallest member of the Inhibitor of apoptosis (IAP) family of proteins, involved
in inhibition of apoptosis and regulation of cell cycle. These functional attributes make …

Cell-penetrating peptides (CPPs) have been discovered to deliver chemical drugs, nucleic
acids, and macromolecules to permeate cell membranes, creating a novel route for …

Apoptosis is a process of programmed cell death in which a cell commits suicide while
maintaining the integrity and architecture of the tissue as a whole. Apoptosis involves …

Survivin is a member of the inhibitor-of-apoptosis proteins (IAPs) family; its overexpression
has been widely demonstrated to occur in various types of cancer. Overexpression of …

Since the discovery of survivin (BIRC5) as a cancer-related molecule by Grazia Ambrosini
and Dario C. Altieri at 1997, our knowledge related to the function of this molecule has been …

X-linked inhibitor of apoptosis protein (XIAP), survivin, and BRUCE are members of the
inhibitor-of-apoptosis protein (IAP) family known for their inhibitory effects on caspase …

Traditional anticancer therapies can cause serious side effects in clinical treatment due to
their nonspecific of tumor cells. Aptamers, also termed as' chemical antibodies', are short …

Aptamers are single-stranded structured oligonucleotides (DNA or RNA) that can bind to a
wide range of targets (“apatopes”) with high affinity and specificity. These nucleic acid …

Survivin, a prominent anticancer target, is ubiquitously expressed in a plethora of cancers
and the evolving complexity in functional regulation of survivin is yet to be deciphered …

Highlights•Survivin is over-expressed in many cancers and an ideal target for drug
discovery.•Survivin is considered “undruggable” due to lack of known enzymatic …