Increases in the intracellular levels of reactive oxygen species (ROS), frequently referred to
as oxidative stress, respresents a potentially toxic insult which if not counteracted will lead to …

Two supergene families encode proteins with glutathione S-transferase (GST) activity: the
family of soluble enzymes comprises at least 16 genes; the separate family of microsomal …

Sequence alignment and phylogenetic analysis has identified a new subgroup of
glutathione S-transferase (GST)-like proteins from a range of species extending from plants …

Objective: To investigate the levels of glutathione transferase (GST), a protective enzyme
against aldehydes, and especially 4-hydroxynonenal (HNE) in the brain and ventricular CSF …

Identifying how genes and their functions evolve after duplication is central to understanding
gene family radiation. In this study, we systematically examined the functional diversification …

The mercapturic acid pathway is a major route for the biotransformation of xenobiotic and
endobiotic electrophilic compounds and their metabolites. Mercapturic acids (N-acetyl-l …

Plant glutathione S-transferases (GSTs) are multifunctional proteins encoded by a large
gene family that play major roles in the detoxification of xenobiotics and oxidative stress …

Human glutathione transferase P1-1 (GSTP1-1) is polymorphic in amino acid residue 105,
positioned in the substrate binding H-site. To elucidate the role of this residue an extensive …

Human serum albumin (HSA) is characterized by 17 disulfides and by only one unpaired
cysteine (Cys34), which can be free in the reduced albumin or linked as a mixed disulfide …

Oxidative damage is proposed as a key mediator of exacerbated morphological responses
and deficits in behavioral recovery in aged subjects with traumatic brain injury (TBI). In the …