Helminths are masterful immunoregulators. A characteristic feature of helminth infection is a
Th2-dominated immune response, but stimulation of immunoregulatory cell populations …

In areas of rural poverty in the tropics and subtropics, more than 700 million persons are
infected with the parasites Necator americanus and Ancylostoma duodenale. The adult …

The scientific study of human hookworm infection began at the dawn of the twentieth
century. In recent years, there have been dramatic improvements in our understanding of …

Summary Background Infection with the Ebola virus induces overexpression of the
procoagulant tissue factor in primate monocytes and macrophages, suggesting that …

Blood-protein digestion is a key physiological process providing essential nutrients for ticks
and is a prerequisite for the transmission of tick-borne pathogens. Recently, substantial …

Interactions between host nutrition and feeding behaviour are central to understanding the
pathophysiological consequences of infections of the digestive tract with parasitic …

The hookworm Necator americanus is the predominant soil-transmitted human parasite.
Adult worms feed on blood in the small intestine, causing iron-deficiency anemia …

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Proteases frequently function not only as individual enzymes but also in cascades or
networks. A notable evolutionary switch occurred in one such protease network that is …

For more than four decades, the free-living nematode Caenorhabditis elegans has been
extensively used in anthelmintic research. Classic genetic screens and heterologous …