Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula

L Zhao, H Zhang, N Li, J Chen, H Xu, Y Wang… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Network pharmacology is a new discipline based on
systems biology theory, biological system network analysis, and multi-target drug molecule …

Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Huanglian Jiedu Decoction against sepsis

X Li, S Wei, S Niu, X Ma, H Li, M **g, Y Zhao - Computers in biology and …, 2022 - Elsevier
Abstract Background Huanglian Jiedu Decoction (HLJDD) is a classical herbal formula with
potential efficacy in the treatment of sepsis. However, the main components and potential …

Graph neural networks: foundation, frontiers and applications

L Wu, P Cui, J Pei, L Zhao, X Guo - … of the 28th ACM SIGKDD Conference …, 2022 - dl.acm.org
The field of graph neural networks (GNNs) has seen rapid and incredible strides over the
recent years. Graph neural networks, also known as deep learning on graphs, graph …

Building a knowledge graph to enable precision medicine

P Chandak, K Huang, M Zitnik - Scientific Data, 2023 - nature.com
Develo** personalized diagnostic strategies and targeted treatments requires a deep
understanding of disease biology and the ability to dissect the relationship between …

In silico methods and tools for drug discovery

B Shaker, S Ahmad, J Lee, C Jung, D Na - Computers in biology and …, 2021 - Elsevier
In the past, conventional drug discovery strategies have been successfully employed to
develop new drugs, but the process from lead identification to clinical trials takes more than …

webTWAS: a resource for disease candidate susceptibility genes identified by transcriptome-wide association study

C Cao, J Wang, D Kwok, F Cui, Z Zhang… - Nucleic acids …, 2022 - academic.oup.com
The development of transcriptome-wide association studies (TWAS) has enabled
researchers to better identify and interpret causal genes in many diseases. However, there …

UniProt: the universal protein knowledgebase in 2021

Nucleic acids research, 2021 - academic.oup.com
The aim of the UniProt Knowledgebase is to provide users with a comprehensive, high-
quality and freely accessible set of protein sequences annotated with functional information …

A knowledge graph to interpret clinical proteomics data

A Santos, AR Colaço, AB Nielsen, L Niu… - Nature …, 2022 - nature.com
Implementing precision medicine hinges on the integration of omics data, such as
proteomics, into the clinical decision-making process, but the quantity and diversity of …

Ensembl 2021

KL Howe, P Achuthan, J Allen, J Allen… - Nucleic acids …, 2021 - academic.oup.com
Abstract The Ensembl project (https://www. ensembl. org) annotates genomes and
disseminates genomic data for vertebrate species. We create detailed and comprehensive …

Open graph benchmark: Datasets for machine learning on graphs

W Hu, M Fey, M Zitnik, Y Dong, H Ren… - Advances in neural …, 2020 - proceedings.neurips.cc
Abstract We present the Open Graph Benchmark (OGB), a diverse set of challenging and
realistic benchmark datasets to facilitate scalable, robust, and reproducible graph machine …