The human immunodeficiency virus type 1 (HIV-1) Vpr protein is an attractive target for
antiretroviral drug development. The conservation both of the structure along virus evolution …

Vpr is a lentiviral accessory protein that is expressed late during the infection cycle and is
packaged in significant quantities into virus particles through a specific interaction with the …

Viruses often interfere with the DNA damage response to better replicate in their hosts. The
human immunodeficiency virus 1 (HIV-1) viral protein R (Vpr) protein has been reported to …

In addition to CD4+ T lymphocytes, myeloid cells and, particularly, differentiated
macrophages are targets of human immunodeficiency virus type-1 (HIV-1) infection via the …

HIV-1 encodes four accesory proteins in addition to its structural and regulatory genes.
Uniquely amongst them, Vpr is abundantly present within virions, meaning it is poised to …

Back in 1989 some studies have shown that the viral protein Vpr was dispensable for HIV-1
replication in vitro. From then the concept of accessory or auxiliary protein for Vpr has …

The HIV-1 accessory protein Vpr displays different activities potentially impacting viral
replication, including the arrest of the cell cycle in the G2 phase and the stimulation of …

Even in the era of combination antiretroviral therapies used to combat human
immunodeficiency virus type 1 (HIV-1) infection, up to 50% of well-suppressed HIV-1 …

Acquired immunodeficiency syndrome (AIDS) occurs when HIV depletes CD4+ helper T
cells. Some patients develop AIDS slowly or not at all, and are termed long-term non …

There is increasing evidence that HIV-1 viral protein R (Vpr) plays an important role in the
pathogenesis of cognitive impairment. We investigated the relationship between HIV-1 …