Transfer RNAs (tRNAs) have been historically viewed as non-dynamic adaptors that decode
the genetic code into proteins. Recent work has uncovered dynamic regulatory roles for …

Aminoacyl-tRNA synthetases (ARSs) are enzymes that catalyze the ligation of amino acids
to tRNAs for translation. Beyond their traditional role in translation, ARSs have acquired …

Tumorigenesis, like most complex genetic traits, is driven by the joint actions of many
mutations. At the nucleotide level, such mutations are cancer-driving nucleotides (CDNs) …

Aminoacyl-tRNA synthetases (ARSs) are essential enzymes that load amino acids to their
cognate tRNA molecules. The expression of certain ARSs and tRNAs has been shown to be …

This study delves into the biomolecular mechanisms underlying the antitumoral efficacy of a
hybrid nanosystem, comprised of a silver core@ shell (Ag@ MSNs) functionalized with …

Endometrial cancer, which is the most common gynaecological cancer in women after
breast, colorectal and lung cancer, can be diagnosed at an early stage. The first aim of this …

Background DARS2 was overexpressed in multiple tumor types, but the biological role of
DARS2 in lung adenocarcinoma (LUAD) have not been elucidated. Methods Firstly, the …

Aminoacyl-tRNA synthetases (AARSs) play an indispensable role in the translation of
mRNAs into proteins. It has become amply clear that AARSs also have non-canonical or non …

Since the breakthrough discovery of N6-methyladenosine (m 6 A), the field of RNA
epitranscriptomics has attracted increasing interest in the biological sciences. Transfer …

Background Osteosarcoma is one of the most malignant tumors, and it occurs mostly in
children and adolescents. Currently, surgery and chemotherapy are the main treatments …