Organoid cultures have emerged as an alternative in vitro system to recapitulate tissues in a
dish. While mouse models and cell lines have furthered our understanding of liver biology …

Acetaminophen (APAP) is the most commonly used drug for the treatment of pain and fever
around the world. At the same time, APAP can cause dose-related hepatocellular necrosis …

Acute liver failure is a rare and severe consequence of abrupt hepatocyte injury, and can
evolve over days or weeks to a lethal outcome. A variety of insults to liver cells result in a …

Background: Because acute liver failure is rare, related data have been sparse. Studies
have suggested that viral hepatitis is the most common underlying cause of this condition …

The hepatitis B virus (HBV), discovered in 1966, infects more than 350 million people
worldwide. 1 Hepatitis B is a leading cause of chronic hepatitis, cirrhosis, and hepatocellular …

BACKGROUND & AIMS: N-acetylcysteine (NAC), an antidote for acetaminophen poisoning,
might benefit patients with non–acetaminophen-related acute liver failure. METHODS: In a …

The widespread availability and frequent use of serum chemistry tests have resulted in a
dramatic increase in the number of normal and abnormal liver chemistry test values that …

Background Limited data are available regarding global hepatitis B virus (HBV)-related
morbidity and mortality and potential reduction in disease burden from hepatitis B …

Consensus guidelines for periprocedural management of coagulation status and hemostasis
risk in percutaneous image-guided interventions Consensus guidelines for periprocedural …

Cirrhosis and chronic liver failure are leading causes of morbidity and mortality in the United
States, with the majority of preventable cases attributed to excessive alcohol consumption …