CRISPR-Cas systems: prokaryotes upgrade to adaptive immunity
Clustered regularly interspaced short palindromic repeats (CRISPR), and associated
proteins (Cas) comprise the CRISPR-Cas system, which confers adaptive immunity against …
proteins (Cas) comprise the CRISPR-Cas system, which confers adaptive immunity against …
A decade of discovery: CRISPR functions and applications
This year marks the tenth anniversary of the identification of the biological function of
CRISPR–Cas as adaptive immune systems in bacteria. In just a decade, the characterization …
CRISPR–Cas as adaptive immune systems in bacteria. In just a decade, the characterization …
Computational approaches to predict bacteriophage–host relationships
Metagenomics has changed the face of virus discovery by enabling the accurate
identification of viral genome sequences without requiring isolation of the viruses. As a …
identification of viral genome sequences without requiring isolation of the viruses. As a …
RNA-guided human genome engineering via Cas9
Bacteria and archaea have evolved adaptive immune defenses, termed clustered regularly
interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems, that …
interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems, that …
CRISPR-mediated adaptive immune systems in bacteria and archaea
Effective clearance of an infection requires that the immune system rapidly detects and
neutralizes invading parasites while strictly avoiding self-antigens that would result in …
neutralizes invading parasites while strictly avoiding self-antigens that would result in …
CRISPR-Cas systems in bacteria and archaea: versatile small RNAs for adaptive defense and regulation
Bacteria and archaea have evolved defense and regulatory mechanisms to cope with
various environmental stressors, including virus attack. This arsenal has been expanded by …
various environmental stressors, including virus attack. This arsenal has been expanded by …
The human microbiome: our second genome
The human genome has been referred to as the blueprint of human biology. In this review
we consider an essential but largely ignored overlay to that blueprint, the human …
we consider an essential but largely ignored overlay to that blueprint, the human …
CRISPR-based adaptive immune systems
CRISPR–Cas systems are recently discovered, RNA-based immune systems that control
invasions of viruses and plasmids in archaea and bacteria. Prokaryotes with CRISPR–Cas …
invasions of viruses and plasmids in archaea and bacteria. Prokaryotes with CRISPR–Cas …
Delivery and use of the CRISPR-Cas systems, vectors and compositions for hepatic targeting and therapy
F Zhang, L Cong, RAN Fei - US Patent 10,577,630, 2020 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
52105121&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
52105121&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Remarkable mechanisms in microbes to resist phage infections
RL Dy, C Richter, GPC Salmond… - Annual review of …, 2014 - annualreviews.org
Bacteriophages (phages) specifically infect bacteria and are the most abundant biological
entities on Earth. The constant exposure to phage infection imposes a strong selective …
entities on Earth. The constant exposure to phage infection imposes a strong selective …