CRISPR-Cas systems: prokaryotes upgrade to adaptive immunity

R Barrangou, LA Marraffini - Molecular cell, 2014 - cell.com
Clustered regularly interspaced short palindromic repeats (CRISPR), and associated
proteins (Cas) comprise the CRISPR-Cas system, which confers adaptive immunity against …

A decade of discovery: CRISPR functions and applications

R Barrangou, P Horvath - Nature microbiology, 2017 - nature.com
This year marks the tenth anniversary of the identification of the biological function of
CRISPR–Cas as adaptive immune systems in bacteria. In just a decade, the characterization …

Computational approaches to predict bacteriophage–host relationships

RA Edwards, K McNair, K Faust, J Raes… - FEMS microbiology …, 2016 - academic.oup.com
Metagenomics has changed the face of virus discovery by enabling the accurate
identification of viral genome sequences without requiring isolation of the viruses. As a …

RNA-guided human genome engineering via Cas9

P Mali, L Yang, KM Esvelt, J Aach, M Guell, JE DiCarlo… - Science, 2013 - science.org
Bacteria and archaea have evolved adaptive immune defenses, termed clustered regularly
interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems, that …

CRISPR-mediated adaptive immune systems in bacteria and archaea

R Sorek, CM Lawrence… - Annual review of …, 2013 - annualreviews.org
Effective clearance of an infection requires that the immune system rapidly detects and
neutralizes invading parasites while strictly avoiding self-antigens that would result in …

CRISPR-Cas systems in bacteria and archaea: versatile small RNAs for adaptive defense and regulation

D Bhaya, M Davison, R Barrangou - Annual review of genetics, 2011 - annualreviews.org
Bacteria and archaea have evolved defense and regulatory mechanisms to cope with
various environmental stressors, including virus attack. This arsenal has been expanded by …

The human microbiome: our second genome

EA Grice, JA Segre - Annual review of genomics and human …, 2012 - annualreviews.org
The human genome has been referred to as the blueprint of human biology. In this review
we consider an essential but largely ignored overlay to that blueprint, the human …

CRISPR-based adaptive immune systems

MP Terns, RM Terns - Current opinion in microbiology, 2011 - Elsevier
CRISPR–Cas systems are recently discovered, RNA-based immune systems that control
invasions of viruses and plasmids in archaea and bacteria. Prokaryotes with CRISPR–Cas …

Delivery and use of the CRISPR-Cas systems, vectors and compositions for hepatic targeting and therapy

F Zhang, L Cong, RAN Fei - US Patent 10,577,630, 2020 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
52105121&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Remarkable mechanisms in microbes to resist phage infections

RL Dy, C Richter, GPC Salmond… - Annual review of …, 2014 - annualreviews.org
Bacteriophages (phages) specifically infect bacteria and are the most abundant biological
entities on Earth. The constant exposure to phage infection imposes a strong selective …