[HTML][HTML] Articular fibrocartilage-Why does hyaline cartilage fail to repair?
Once damaged, articular cartilage has a limited potential to repair. Clinically, a repair tissue
is formed, yet, it is often mechanically inferior fibrocartilage. The use of monolayer expanded …
is formed, yet, it is often mechanically inferior fibrocartilage. The use of monolayer expanded …
Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics
General trends in synthetic bone grafting materials are shifting towards approaches that can
illicit osteoinductive properties. Pharmacologics and biologics have been used in …
illicit osteoinductive properties. Pharmacologics and biologics have been used in …
3D printed microchannel networks to direct vascularisation during endochondral bone repair
Bone tissue engineering strategies that recapitulate the developmental process of
endochondral ossification offer a promising route to bone repair. Clinical translation of such …
endochondral ossification offer a promising route to bone repair. Clinical translation of such …
Chondrocyte hypertrophy in osteoarthritis: mechanistic studies and models for the identification of new therapeutic strategies
Articular cartilage shows limited self-healing ability owing to its low cellularity and
avascularity. Untreated cartilage defects display an increased propensity to degenerate …
avascularity. Untreated cartilage defects display an increased propensity to degenerate …
3D bioprinting of hydrogel constructs with cell and material gradients for the regeneration of full-thickness chondral defect using a microfluidic printing head
Osteochondral (OC) tissue is a biphasic material comprised of articular cartilage integrated
atop subchondral bone. Damage to this tissue is highly problematic, owing to its intrinsic …
atop subchondral bone. Damage to this tissue is highly problematic, owing to its intrinsic …
Targeting TGFβ signaling in subchondral bone and articular cartilage homeostasis
Osteoarthritis (OA) is the most common degenerative joint disease and no disease-
modifying therapy for OA is currently available. Targeting articular cartilage alone may not …
modifying therapy for OA is currently available. Targeting articular cartilage alone may not …
Strategies to develop endogenous stem cell-recruiting bioactive materials for tissue repair and regeneration
A leading strategy in tissue engineering is the design of biomimetic scaffolds that stimulate
the body's repair mechanisms through the recruitment of endogenous stem cells to sites of …
the body's repair mechanisms through the recruitment of endogenous stem cells to sites of …
[HTML][HTML] Strategies to minimize hypertrophy in cartilage engineering and regeneration
S Chen, P Fu, R Cong, HS Wu, M Pei - Genes & diseases, 2015 - Elsevier
Due to a blood supply shortage, articular cartilage has a limited capacity for self-healing
once damaged. Articular chondrocytes, cartilage progenitor cells, embryonic stem cells, and …
once damaged. Articular chondrocytes, cartilage progenitor cells, embryonic stem cells, and …
Enhancing chondrogenic phenotype for cartilage tissue engineering: monoculture and coculture of articular chondrocytes and mesenchymal stem cells
KM Hubka, RL Dahlin, VV Meretoja… - … Engineering Part B …, 2014 - liebertpub.com
Articular cartilage exhibits an inherently low rate of regeneration. Consequently, damage to
articular cartilage often requires surgical intervention. However, existing treatments …
articular cartilage often requires surgical intervention. However, existing treatments …
NSAID therapy effects on healing of bone, tendon, and the enthesis
B Su, JP O'Connor - Journal of applied physiology, 2013 - journals.physiology.org
Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for the treatment of
skeletal injuries. The ability of NSAIDs to reduce pain and inflammation is well-established …
skeletal injuries. The ability of NSAIDs to reduce pain and inflammation is well-established …