The conversion of native peptides and proteins into amyloid aggregates is a hallmark of over
50 human disorders, including Alzheimer's and Parkinson's diseases. Increasing evidence …

Self-assembled peptide and protein amyloid nanostructures have traditionally been
considered only as pathological aggregates implicated in human neurodegenerative …

Aggregation of alpha-synuclein (α-Syn) drives Parkinson's disease (PD), although the initial
stages of self-assembly and structural conversion have not been directly observed inside …

The self-assembly of α-synuclein (αS) into intraneuronal inclusion bodies is a key
characteristic of Parkinson's disease. To define the nature of the species giving rise to …

Protein aggregation and abnormal lipid homeostasis are both implicated in
neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate …

The cardinal motor symptoms of Parkinson's disease (PD) are caused by the death of
dopaminergic neurons in the substantia nigra pars compacta (SN c). Alpha‐synuclein …

Alpha-synuclein (αS) is the major constituent of Lewy bodies and a pathogenic hallmark of
all synucleinopathathies, including Parkinson's disease (PD), dementia with Lewy bodies …

Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder
producing progressive cognitive decline that interferes with normal life and daily activities …

Thioflavin T (ThT) has been widely used to investigate amyloid formation since 1989. While
concerns have recently been raised about its use as a probe specific for amyloid, ThT still …

The number of biological therapeutic agents in the clinic and development pipeline has
increased dramatically over the last decade and the number will undoubtedly continue to …