Induced pluripotent stem cell (iPSC) technologies have provided in vitro models of
inaccessible human cell types, yielding new insights into disease mechanisms especially for …

The introduction of induced pluripotent stem cells (iPSCs) has opened up the potential for
personalized cell therapies and ushered in new opportunities for regenerative medicine …

Technology utilizing human induced pluripotent stem cells (iPS cells) has enormous
potential to provide improved cellular models of human disease. However, variable genetic …

Fibrillin is a large evolutionarily ancient extracellular glycoprotein that assembles to form
beaded microfibrils which are essential components of most extracellular matrices. Fibrillin …

Cardiotoxicity is a severe side effect of drugs that induce structural or electrophysiological
changes in heart muscle cells. As a result, the heart undergoes failure and potentially lethal …

Interferon-induced transmembrane protein 3 (IFITM3) is a restriction factor that limits viral
pathogenesis and exerts poorly understood immunoregulatory functions. Here, using human …

Induced pluripotent stem cells (iPSCs) are valuable in disease modeling because of their
potential to expand and differentiate into virtually any cell type and recapitulate key aspects …

Abstract The Human Induced Pluripotent Stem Cell Initiative (HipSci) isf establishing a large
catalogue of human iPSC lines, arguably the most well characterized collection to date. The …

Organoid-based models of murine and human innate lymphoid cell precursor (ILCP)
maturation are presented. First, murine intestinal and pulmonary organoids are harnessed to …

Heterogeneity in cell function has presented a significant hurdle to the successful clinical
translation of many cellular therapies. Current techniques for assessing cell quality and the …