The opioid system consists of three receptors, mu, delta, and kappa, which are activated by
endogenous opioid peptides processed from three protein precursors, proopiomelanocortin …

Opioid-related overdose deaths have reached epidemic levels within the last decade. The
efforts to prevent, identify, and treat opioid use disorders (OUDs) mostly focus on the …

Opioid receptors are G protein-coupled receptors (GPCRs) that modulate brain function at
all levels of neural integration, including autonomic, sensory, emotional and cognitive …

Alterations in the brain's μ-opioid receptor (MOR) system have been associated with several
neuropsychiatric disorders. Central MOR availability also varies considerably in healthy …

Obesity is highly prevalent among patients with schizophrenia and is associated with
detrimental health consequences. Although excessive consumption of fast food and …

In vivo functional imaging by means of positron emission tomography (PET) is the sole
method for providing a quantitative measurement of μ-, κ and δ-opioid receptor-mediated …

Objective: To provide an overview of treatment options for opioid-dependent patients.
Method: We screened all published studies on the treatment of opioid dependence, with a …

Background: Pharmacotherapy of alcohol dependence (AD) is at an early stage of
development; currently available medications have limited efficacy. It would be clinically …

It has been recently suggested that activation of 5-HT4 receptors might exert antidepressant-
like effects in rats after 3 d treatment, suggesting a new strategy for develo** faster-acting …

This systematic review summarises evidence of the effectiveness of naltrexone (NTX) and
the added value of psychosocial treatment in the maintenance treatment of opioid and …