The directed aldol reaction allows the construction of new carbon–carbon bonds in a regio‐,
diastereo‐, and enantioselective manner. The kinetically controlled, boron‐mediated aldol …

Nature presents us countless numbers of natural products with complex and fascinating
structures and useful properties. Macrodiolides belong to one relatively small but interesting …

High selectivity in carbanion chemistry can be obtained, if the counterion, traditionally a
main group element, is replaced by a transition metal. Titanium reagents have been applied …

1. Introduction Nature has stocked the seas with a seemingly limitless range of diverse and
often highly complex secondary metabolites, which exhibit one or more of a variety of …

The total synthesis of the marine macrolide bryostatin 2 is described. The synthesis plan
relies on aldol and directed reduction steps in order to construct the anti-1, 3-diol array …

The state-of-the-art in stereoselective synthesis!. Thoroughly revised and updated, this
enlarged second edition offers a plethora of valuable information on methods and reagents …

Enol diisopinocampheylborinates, derived from achiral ethyl and methyl ketones by
enolisation in the presence of tertiary amine bases (iPr2NEt or Et3N), undergo enantio-and …

Four decades since Mukaiyama's first reports on the successful application of silicon and
boron enolates in directed aldol reactions, the ability of this highly controlled carbon–carbon …

A practical stereocontrolled synthesis of (+)-discodermolide (1) has been completed in
10.3% overall yield (23 steps longest linear sequence). The absolute stereochemistry of the …

Scheme 2. Synthesis of the C5±C17 subunit 14: a) toluene, À788C, 5 min; LDA, THF,
À788C, 15 min; b) TBSCl, Im, CH2Cl2, 208C, 1 h; c) 1)(c-Hex) 2BCl, Et3N, Et2O, À58C, 1 h; …