Protein phosphorylation is a major regulator of protein function and biological outcomes.
This was first recognized through functional biochemical experiments, and in the past …

Translation is a key step in the regulation of gene expression and one of the most energy-
consuming processes in the cell. In response to various stimuli, multiple signaling pathways …

Reversible protein phosphorylation is a central signaling mechanism in eukaryotes.
Although mass-spectrometry-based phosphoproteomics has become routine, identification …

Mass spectrometry (MS) coupled toisobaric labeling has developed rapidly into a powerful
strategy for high-throughput protein quantification. Sample multiplexing and exceptional …

According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

Abstract PhosphoSitePlus (http://www. phosphosite. org) is an open, comprehensive,
manually curated and interactive resource for studying experimentally observed post …

Cross-talk between different types of post-translational modifications on the same protein
molecule adds specificity and combinatorial logic to signal processing, but it has not been …

Neurofibromin is a large and multifunctional protein encoded by the tumor suppressor gene
NF1, mutations of which cause the tumor predisposition syndrome neurofibromatosis type 1 …

Quantitative mass spectrometry–based proteomics is highly versatile but not easily
multiplexed. Isobaric labeling strategies allow mass spectrometry–based multiplexed …

Mass-spectrometry-based proteomics is continuing to make major contributions to the
discovery of fundamental biological processes and, more recently, has also developed into …