Activation of human endogenous retroviruses and its physiological consequences
Human endogenous retroviruses (HERVs) are abundant sequences that persist within the
human genome as remnants of ancient retroviral infections. These sequences became fixed …
human genome as remnants of ancient retroviral infections. These sequences became fixed …
Measuring and interpreting transposable element expression
Transposable elements (TEs) are insertional mutagens that contribute greatly to the
plasticity of eukaryotic genomes, influencing the evolution and adaptation of species as well …
plasticity of eukaryotic genomes, influencing the evolution and adaptation of species as well …
From telomere to telomere: The transcriptional and epigenetic state of human repeat elements
SJ Hoyt, JM Storer, GA Hartley, PGS Grady… - Science, 2022 - science.org
Mobile elements and repetitive genomic regions are sources of lineage-specific genomic
innovation and uniquely fingerprint individual genomes. Comprehensive analyses of such …
innovation and uniquely fingerprint individual genomes. Comprehensive analyses of such …
Population genomics confirms acquisition of drug-resistant Aspergillus fumigatus infection by humans from the environment
Infections caused by the fungal pathogen Aspergillus fumigatus are increasingly resistant to
first-line azole antifungal drugs. However, despite its clinical importance, little is known …
first-line azole antifungal drugs. However, despite its clinical importance, little is known …
Enzymatic methyl sequencing detects DNA methylation at single-base resolution from picograms of DNA
Bisulfite sequencing detects 5mC and 5hmC at single-base resolution. However, bisulfite
treatment damages DNA, which results in fragmentation, DNA loss, and biased sequencing …
treatment damages DNA, which results in fragmentation, DNA loss, and biased sequencing …
A prenylated dsRNA sensor protects against severe COVID-19
INTRODUCTION Interferons (IFNs) are cytokines that are rapidly deployed in response to
invading pathogens. By initiating a signaling cascade that stimulates the expression of …
invading pathogens. By initiating a signaling cascade that stimulates the expression of …
N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription
N 6-methyladenosine (m6A) regulates stability and translation of messenger RNA (mRNA)
in various biological processes. In this work, we show that knockout of the m6A writer Mettl3 …
in various biological processes. In this work, we show that knockout of the m6A writer Mettl3 …
RepeatModeler2 for automated genomic discovery of transposable element families
The accelerating pace of genome sequencing throughout the tree of life is driving the need
for improved unsupervised annotation of genome components such as transposable …
for improved unsupervised annotation of genome components such as transposable …
Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation
The biological function of Z-DNA and Z-RNA, nucleic acid structures with a left-handed
double helix, is poorly understood,–. Z-DNA-binding protein 1 (ZBP1; also known as DAI or …
double helix, is poorly understood,–. Z-DNA-binding protein 1 (ZBP1; also known as DAI or …
Atlas of subcellular RNA localization revealed by APEX-Seq
We introduce APEX-seq, a method for RNA sequencing based on direct proximity labeling of
RNA using the peroxidase enzyme APEX2. APEX-seq in nine distinct subcellular locales …
RNA using the peroxidase enzyme APEX2. APEX-seq in nine distinct subcellular locales …