Homocysteine metabolism
J Selhub - Annual review of nutrition, 1999 - annualreviews.org
▪ Abstract Homocysteine is a sulfur amino acid whose metabolism stands at the intersection
of two pathways: remethylation to methionine, which requires folate and vitamin B12 (or …
of two pathways: remethylation to methionine, which requires folate and vitamin B12 (or …
5, 10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review
LD Botto, Q Yang - American journal of epidemiology, 2000 - academic.oup.com
Abstract The enzyme 5, 10-methylenetetrahydrofolate reductase (MTHFR) is involved in
folate metabolism. The MTHFR gene is located on chromosome 1 (1p36. 3), and two …
folate metabolism. The MTHFR gene is located on chromosome 1 (1p36. 3), and two …
MTHFR 677C→ T polymorphism and risk of coronary heart disease: a meta-analysis
M Klerk, P Verhoef, R Clarke, HJ Blom, FJ Kok… - Jama, 2002 - jamanetwork.com
ContextIn observational studies, individuals with elevated levels of plasma homocysteine
tend to have moderately increased risk of coronary heart disease (CHD). The MTHFR …
tend to have moderately increased risk of coronary heart disease (CHD). The MTHFR …
A common mutation in the 5, 10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status
DNA methylation, an essential epigenetic feature of DNA that modulates gene expression
and genomic integrity, is catalyzed by methyltransferases that use the universal methyl …
and genomic integrity, is catalyzed by methyltransferases that use the universal methyl …
[HTML][HTML] The controversy over homocysteine and cardiovascular risk
PM Ueland, H Refsum, SAA Beresford… - The American journal of …, 2000 - Elsevier
Elevated plasma total homocysteine (tHcy) is a risk factor for occlusive cardiovascular
disease (CVD). This concept is based on the observations of premature vascular disease in …
disease (CVD). This concept is based on the observations of premature vascular disease in …
[HTML][HTML] Homocysteine and cardiovascular disease: cause or effect?
L Brattström, DEL Wilcken - The American journal of clinical nutrition, 2000 - Elsevier
Both markedly and mildly elevated circulating homocysteine concentrations are associated
with increased risk of vascular occlusion. Here we review possible mechanisms that mediate …
with increased risk of vascular occlusion. Here we review possible mechanisms that mediate …
Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review
L Sharp, J Little - American journal of epidemiology, 2004 - academic.oup.com
Epidemiologic and mechanistic evidence suggests that folate is involved in colorectal
neoplasia. Some polymorphic genes involved in folate metabolism …
neoplasia. Some polymorphic genes involved in folate metabolism …
Association between factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations and events of the arterial circulatory system: a …
RJ Kim, RC Becker - American heart journal, 2003 - Elsevier
BACKGROUND: The association between the inherited gene mutations of factor V,
prothrombin, and homocysteine metabolism and venous thromboembolic events is accepted …
prothrombin, and homocysteine metabolism and venous thromboembolic events is accepted …
Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism …
DNA methylation is an epigenetic feature of DNA that influences cellular development and
function, and aberrations of DNA methylation are a candidate mechanism for the …
function, and aberrations of DNA methylation are a candidate mechanism for the …
[HTML][HTML] Gene-nutrient interactions and DNA methylation
Many micronutrients and vitamins are critical for DNA synthesis/repair and maintenance of
DNA methylation patterns. Folate has been most extensively investigated in this regard …
DNA methylation patterns. Folate has been most extensively investigated in this regard …