Genetic decoding is not 'frozen'as was earlier thought, but dynamic. One facet of this is
frameshifting that often results in synthesis of a C-terminal region encoded by a new frame …

In metazoans mitochondrial DNA (mtDNA) or retrotransposon cDNA released to cytoplasm
are degraded by nucleases to prevent sterile inflammation. It remains unknown whether …

Retrotransposons are mobile DNA elements that are more active with increasing age and
exacerbate aging phenotypes in multiple species. We previously reported an unexpected …

Chromatin is a highly dynamic biological entity that allows for both the control of gene
expression and the stabilization of chromosomal domains. Given the high degree of …

Beyond their canonical function in nucleocytoplasmic exchanges, nuclear pore complexes
(NPCs) regulate the expression of protein-coding genes. Here, we have implemented …

The Ty1 retrotransposons present in the genome of Saccharomyces cerevisiae belong to the
large class of mobile genetic elements that replicate via an RNA intermediary and constitute …

Transposons can impact the host genome by altering gene expression and participating in
chromosome rearrangements. Therefore, organisms evolved different ways to minimize the …

Most ribosomal proteins in Saccharomyces cerevisiae are encoded by two paralogs that
additively produce the optimal protein level for cell growth. Nonetheless, deleting one …

Retroviruses and Long Terminal Repeat (LTR)-retrotransposons have distinct patterns of
integration sites. The oncogenic potential of retrovirus-based vectors used in gene therapy is …

The Ty1 retrotransposon family is maintained in a functional but dormant state by its host,
Saccharomyces cerevisiae. Several hundred RHF and RTT genes encoding co-factors and …