Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience

KA Wilson, M Chamoli, TA Hilsabeck, M Pandey… - Cell metabolism, 2021 - cell.com
Dietary restriction (DR) has long been viewed as the most robust nongenetic means to
extend lifespan and healthspan. Many aging-associated mechanisms are nutrient …

[HTML][HTML] Gender-specific effects of pro-longevity interventions in Drosophila

O Lushchak, O Strilbytska, KB Storey - Mechanisms of ageing and …, 2023 - Elsevier
Sex differences in lifespan are well recognized in the majority of animal species. For
example, in male versus female Drosophila melanogaster there are significant differences in …

A new AMPK isoform mediates glucose-restriction induced longevity non-cell autonomously by promoting membrane fluidity

JH Jeong, JS Han, Y Jung, SM Lee, SH Park… - Nature …, 2023 - nature.com
Dietary restriction (DR) delays aging and the onset of age-associated diseases. However, it
is yet to be determined whether and how restriction of specific nutrients promote longevity …

A dietary sterol trade-off determines lifespan responses to dietary restriction in Drosophila melanogaster females

B Zanco, CK Mirth, CM Sgrò, MDW Piper - Elife, 2021 - elifesciences.org
Diet plays a significant role in maintaining lifelong health. In particular, lowering the dietary
protein: carbohydrate ratio can improve lifespan. This has been interpreted as a direct effect …

Drosophila melanogaster as a Model Organism for Obesity and Type-2 Diabetes Mellitus by Applying High-Sugar and High-Fat Diets

N Baenas, AE Wagner - Biomolecules, 2022 - mdpi.com
Several studies have been published introducing Drosophila melanogaster as a research
model to investigate the effects of high-calorie diets on metabolic dysfunctions. However …

Intake of polyamide microplastics affects the behavior and metabolism of Drosophila

L Zhong, H **, H Tang, Y Xu, X Liu, J Shen - Chemosphere, 2022 - Elsevier
In this study, the effects of polyamide (PA) microplastics on Drosophila were studied by
analysing their effects on feeding, fecundity, metabolism and spontaneous activity, using …

Beyond calorie restriction: aging as a biological target for nutrient therapies

SN Austad, JM Hoffman - Current opinion in biotechnology, 2021 - Elsevier
Arguably, the most important discovery in the biology of aging to date was that simply
reducing food intake extended life and improved many aspects of health in a diversity of …

Female-biased upregulation of insulin pathway activity mediates the sex difference in Drosophila body size plasticity

JW Millington, GP Brownrigg, C Chao, Z Sun… - Elife, 2021 - elifesciences.org
Nutrient-dependent body size plasticity differs between the sexes in most species, including
mammals. Previous work in Drosophila showed that body size plasticity was higher in …

Bioorthogonal Stimulated Raman Scattering Imaging Uncovers Lipid Metabolic Dynamics in Drosophila Brain During Aging

Y Li, P Chang, S Sankaran, H Jang, Y Nie… - GEN …, 2023 - liebertpub.com
Studies have shown that brain lipid metabolism is associated with biological aging and
influenced by dietary and genetic manipulations; however, the underlying mechanisms are …

Drosophila suzukii energetic pathways are differently modulated by nutritional geometry in males and females

S Sario, RJ Mendes, F Gonçalves, L Torres… - Scientific Reports, 2022 - nature.com
As a polyphagous pest, Drosophila suzukii has a variety of host fruits available for feeding
and oviposition, but how the nutritional geometry of different hosts influences its metabolism …