Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience
Dietary restriction (DR) has long been viewed as the most robust nongenetic means to
extend lifespan and healthspan. Many aging-associated mechanisms are nutrient …
extend lifespan and healthspan. Many aging-associated mechanisms are nutrient …
[HTML][HTML] Gender-specific effects of pro-longevity interventions in Drosophila
Sex differences in lifespan are well recognized in the majority of animal species. For
example, in male versus female Drosophila melanogaster there are significant differences in …
example, in male versus female Drosophila melanogaster there are significant differences in …
A new AMPK isoform mediates glucose-restriction induced longevity non-cell autonomously by promoting membrane fluidity
JH Jeong, JS Han, Y Jung, SM Lee, SH Park… - Nature …, 2023 - nature.com
Dietary restriction (DR) delays aging and the onset of age-associated diseases. However, it
is yet to be determined whether and how restriction of specific nutrients promote longevity …
is yet to be determined whether and how restriction of specific nutrients promote longevity …
A dietary sterol trade-off determines lifespan responses to dietary restriction in Drosophila melanogaster females
Diet plays a significant role in maintaining lifelong health. In particular, lowering the dietary
protein: carbohydrate ratio can improve lifespan. This has been interpreted as a direct effect …
protein: carbohydrate ratio can improve lifespan. This has been interpreted as a direct effect …
Drosophila melanogaster as a Model Organism for Obesity and Type-2 Diabetes Mellitus by Applying High-Sugar and High-Fat Diets
N Baenas, AE Wagner - Biomolecules, 2022 - mdpi.com
Several studies have been published introducing Drosophila melanogaster as a research
model to investigate the effects of high-calorie diets on metabolic dysfunctions. However …
model to investigate the effects of high-calorie diets on metabolic dysfunctions. However …
Intake of polyamide microplastics affects the behavior and metabolism of Drosophila
L Zhong, H **, H Tang, Y Xu, X Liu, J Shen - Chemosphere, 2022 - Elsevier
In this study, the effects of polyamide (PA) microplastics on Drosophila were studied by
analysing their effects on feeding, fecundity, metabolism and spontaneous activity, using …
analysing their effects on feeding, fecundity, metabolism and spontaneous activity, using …
Beyond calorie restriction: aging as a biological target for nutrient therapies
Arguably, the most important discovery in the biology of aging to date was that simply
reducing food intake extended life and improved many aspects of health in a diversity of …
reducing food intake extended life and improved many aspects of health in a diversity of …
Female-biased upregulation of insulin pathway activity mediates the sex difference in Drosophila body size plasticity
JW Millington, GP Brownrigg, C Chao, Z Sun… - Elife, 2021 - elifesciences.org
Nutrient-dependent body size plasticity differs between the sexes in most species, including
mammals. Previous work in Drosophila showed that body size plasticity was higher in …
mammals. Previous work in Drosophila showed that body size plasticity was higher in …
Bioorthogonal Stimulated Raman Scattering Imaging Uncovers Lipid Metabolic Dynamics in Drosophila Brain During Aging
Studies have shown that brain lipid metabolism is associated with biological aging and
influenced by dietary and genetic manipulations; however, the underlying mechanisms are …
influenced by dietary and genetic manipulations; however, the underlying mechanisms are …
Drosophila suzukii energetic pathways are differently modulated by nutritional geometry in males and females
As a polyphagous pest, Drosophila suzukii has a variety of host fruits available for feeding
and oviposition, but how the nutritional geometry of different hosts influences its metabolism …
and oviposition, but how the nutritional geometry of different hosts influences its metabolism …