The endocannabinoid system (eCB) has been studied to identify the molecular structures
present in Cannabis sativa. eCB consists of cannabinoid receptors, endogenous ligands …

Chronic neuropathic pain is a debilitating pain syndrome caused by damage to the nervous
system that is poorly served by current medications. Given these problems, clinical studies …

Neuropathic pain remains prevalent and challenging to manage and is often comorbid with
depression and anxiety. The new approach that simultaneously targets neuropathic pain …

Neuropathic pain is a condition that impacts a substantial portion of the population and is
expected to affect a larger percentage in the future. This type of pain is poorly managed by …

Introduction: Cannabis contains cannabidiol (CBD), the main non-psychoactive
phytocannabinoid, but also many other phytocannabinoids that have therapeutic potential in …

Abstract Delta-9-tetrahydrocannabinol (Δ9-THC) is known to produce systemic analgesia
that involves CB1 and CB2 cannabinoid receptors. However, there is compelling evidence …

ABSTRACT The National Center for Complementary and Integrative Health (NCCIH), which
is part of the US National Institutes of Health (NIH), has a broad interest in studying the …

Abstract Background Δ9-Tetrahydrocannabinol (Δ9-THC) is a principal psychoactive extract
of Cannabis sativa and has been traditionally used as palliative medicine for neuropathic …

Chronic pain patients report analgesic effects when using cannabidiol (CBD), a
phytocannabinoid found in whole-plant cannabis extract (WPE). Several studies suggest …

Introduction: Cannabis extracts are being increasingly used to mitigate chronic pain. Current
guidelines for their prescription rely on Δ9-tetrahydrocannabinol (THC) and cannabidiol …