Advances in diagnosis and management of cancer of the esophagus

N Deboever, CM Jones, K Yamashita, JA Ajani… - Bmj, 2024 - bmj.com
Esophageal cancer is the seventh most common malignancy worldwide, with over 470 000
new cases diagnosed each year. Two distinct histological subtypes predominate, and …

Neoadjuvant chemotherapy with or without camrelizumab in resectable esophageal squamous cell carcinoma: the randomized phase 3 ESCORT-NEO/NCCES01 trial

J Qin, L Xue, A Hao, X Guo, T Jiang, Y Ni, S Liu… - Nature medicine, 2024 - nature.com
Recent single-arm studies involving neoadjuvant camrelizumab, a PD-1 inhibitor, plus
chemotherapy for resectable locally advanced esophageal squamous cell carcinoma (LA …

Perioperative immunotherapy for esophageal squamous cell carcinoma: Now and future

Y Liu - World Journal of Gastroenterology, 2023 - pmc.ncbi.nlm.nih.gov
Esophageal cancer (EC) ranks among the most prevalent malignant tumors affecting the
digestive tract. Esophageal squamous cell carcinoma (ESCC) stands as the prevailing …

Intratumoral microbiota composition regulates chemoimmunotherapy response in esophageal squamous cell carcinoma

H Wu, X Leng, Q Liu, T Mao, T Jiang, Y Liu, F Li… - Cancer …, 2023 - aacrjournals.org
Neoadjuvant chemoimmunotherapy (NACI) has shown promise in the treatment of
resectable esophageal squamous cell carcinoma (ESCC). The microbiomes of patients can …

Comparing a PD-L1 inhibitor plus chemotherapy to chemotherapy alone in neoadjuvant therapy for locally advanced ESCC: a randomized Phase II clinical trial: A …

Y Li, A Zhou, S Liu, M He, K Chen, Z Tian, Y Li, J Qin… - BMC medicine, 2023 - Springer
Abstract Background A Phase II study was undertaken to evaluate the safety and efficacy of
the neoadjuvant socazolimab, a novel PD-L1 inhibitor, in combination with nab-paclitaxel …

Efficacy and safety of camrelizumab in combination with neoadjuvant chemotherapy for ESCC and its impact on esophagectomy

Y Qiao, C Zhao, X Li, J Zhao, Q Huang, Z Ding… - Frontiers in …, 2022 - frontiersin.org
Background Esophageal squamous cell carcinoma (ESCC) is the most common type of
esophageal cancer in China. The use of neoadjuvant immunotherapy for the treatment of …

A prospective study of neoadjuvant pembrolizumab plus chemotherapy for resectable esophageal squamous cell carcinoma: The Keystone-001 trial

X Shang, Y **e, J Yu, C Zhang, G Zhao, F Liang, L Liu… - Cancer Cell, 2024 - cell.com
In this phase II study, 47 patients with locally advanced, resectable esophageal squamous
cell carcinoma (ESCC) received three cycles of pembrolizumab plus chemotherapy …

Advancing esophageal cancer treatment: immunotherapy in neoadjuvant and adjuvant settings

D Park, WJ Jeon, C Yang, DR Castillo - Cancers, 2024 - mdpi.com
Simple Summary The management of locally advanced esophageal cancer poses
considerable challenges and current strategies have significant risks. Moreover, despite …

Survival benefit and spatial properties of tertiary lymphoid structures in esophageal squamous cell carcinoma with neoadjuvant therapies

H Huang, G Zhao, T Wang, Y You, T Zhang, X Chen… - Cancer Letters, 2024 - Elsevier
Tertiary lymphoid structures (TLSs) were associated with survival in esophageal squamous
cell carcinoma (ESCC) undergoing surgery alone (SA). However, their clinical relevance in …

Radiotherapy combined with immune checkpoint inhibitors in locally advanced/metastatic esophageal squamous cell carcinoma: clinical trials, efficacy and future …

M Jiang, Y Hu, G Lin, C Chen, H Li - Frontiers in Immunology, 2023 - frontiersin.org
Esophageal squamous cell carcinoma (ESCC) is a common malignancy worldwide and
often diagnosed at advanced stages with poor prognosis. Combination of radiotherapy and …