A comprehensive review of multi-target directed ligands in the treatment of Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia affecting specifically older
population. AD is an irreversible neurodegenerative CNS disorder associated with complex …
population. AD is an irreversible neurodegenerative CNS disorder associated with complex …
Recent Advances in Medicinal Chemistry of Memantine Against Alzheimer's Disease
YP Singh, H Kumar - Chemical Biology & Drug Design, 2024 - Wiley Online Library
Alzheimer's disease (AD) is a chronic progressive, age‐related neurodegenerative brain
disorder characterized by the irreversible decline of memory and other cognitive functions. It …
disorder characterized by the irreversible decline of memory and other cognitive functions. It …
[HTML][HTML] Indole-3 carbinol and diindolylmethane mitigated β-amyloid-induced neurotoxicity and acetylcholinesterase enzyme activity: in silico, in vitro, and network …
Background: Alzheimer's disease (AD) is a neurodegenerative disease characterized by
beta-amyloid (Aβ) deposition and increased acetylcholinesterase (AchE) enzyme activities …
beta-amyloid (Aβ) deposition and increased acetylcholinesterase (AchE) enzyme activities …
Unravelling neuroregenerative and neuroprotective roles of Wnt/β-catenin pathway in ischemic stroke: Insights into molecular mechanisms
S Yadava, DH Reddy, VP Nakka, VL Anusha… - Neuroscience, 2025 - Elsevier
Stroke is a serious condition often resulting in mortality or long-term disability, causing
cognitive, memory, and motor impairments. A reduction in cerebral blood flow below critical …
cognitive, memory, and motor impairments. A reduction in cerebral blood flow below critical …
Morin attenuated the global cerebral ischemia via antioxidant, anti-inflammatory, and antiapoptotic mechanisms in rats
Global cerebral ischemia is one of the major causes of memory and cognitive impairment.
Hyperactivation of acetylcholine esterase (AChE), oxidative stress, and inflammation are …
Hyperactivation of acetylcholine esterase (AChE), oxidative stress, and inflammation are …
Development of novel 9H-carbazole-4H-chromene hybrids as dual cholinesterase inhibitors for the treatment of Alzheimer's disease
N Sharon, VG Ugale, P Padmaja, D Lokwani… - Molecular Diversity, 2025 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease affecting mental ability and
neurocognitive functions. Cholinesterase enzymes affect concentration of acetylcholine in …
neurocognitive functions. Cholinesterase enzymes affect concentration of acetylcholine in …
NMDA Receptor Antagonists: Emerging Insights into Molecular Mechanisms and Clinical Applications in Neurological Disorders
Neurodegenerative disorders (NDs) include a range of chronic conditions characterized by
progressive neuronal loss, leading to cognitive, motor, and behavioral impairments …
progressive neuronal loss, leading to cognitive, motor, and behavioral impairments …
[HTML][HTML] Analysis of skeletal diversity of multi-target directed ligands (MTDLs) targeting Alzheimer's disease
Alzheimer's disease (AD) remains a significant healthcare challenge, necessitating
innovative therapeutic approaches to address its complex and multifactorial nature …
innovative therapeutic approaches to address its complex and multifactorial nature …
Tangeretin confers neuroprotection, cognitive and memory enhancement in global cerebral ischemia in rats
Global cerebral ischemia is commonly associated with neurological deficits, including
cognitive and memory impairments. The present study aims to investigate the …
cognitive and memory impairments. The present study aims to investigate the …
Asymmetric aza-Henry reaction toward trifluoromethyl β-nitroamines and biological investigation of their adamantane-type derivatives
Y Ren, M Du, Z Peng, C Zheng, G Zhao - Frontiers in Chemistry, 2024 - frontiersin.org
Amino acid-derived quaternary ammonium salts were successfully applied in the
asymmetric aza-Henry reaction of nitromethane to N-Boc trifluoromethyl ketimines. α …
asymmetric aza-Henry reaction of nitromethane to N-Boc trifluoromethyl ketimines. α …