A comprehensive review of multi-target directed ligands in the treatment of Alzheimer's disease

C Pathak, UD Kabra - Bioorganic Chemistry, 2024 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia affecting specifically older
population. AD is an irreversible neurodegenerative CNS disorder associated with complex …

Recent Advances in Medicinal Chemistry of Memantine Against Alzheimer's Disease

YP Singh, H Kumar - Chemical Biology & Drug Design, 2024 - Wiley Online Library
Alzheimer's disease (AD) is a chronic progressive, age‐related neurodegenerative brain
disorder characterized by the irreversible decline of memory and other cognitive functions. It …

[HTML][HTML] Indole-3 carbinol and diindolylmethane mitigated β-amyloid-induced neurotoxicity and acetylcholinesterase enzyme activity: in silico, in vitro, and network …

K Ramakrishna, P Karuturi, Q Siakabinga, G TA… - Diseases, 2024 - mdpi.com
Background: Alzheimer's disease (AD) is a neurodegenerative disease characterized by
beta-amyloid (Aβ) deposition and increased acetylcholinesterase (AchE) enzyme activities …

Unravelling neuroregenerative and neuroprotective roles of Wnt/β-catenin pathway in ischemic stroke: Insights into molecular mechanisms

S Yadava, DH Reddy, VP Nakka, VL Anusha… - Neuroscience, 2025 - Elsevier
Stroke is a serious condition often resulting in mortality or long-term disability, causing
cognitive, memory, and motor impairments. A reduction in cerebral blood flow below critical …

Morin attenuated the global cerebral ischemia via antioxidant, anti-inflammatory, and antiapoptotic mechanisms in rats

N Alla, S Palatheeya, SR Challa, R Kakarla - Metabolic Brain Disease, 2024 - Springer
Global cerebral ischemia is one of the major causes of memory and cognitive impairment.
Hyperactivation of acetylcholine esterase (AChE), oxidative stress, and inflammation are …

Development of novel 9H-carbazole-4H-chromene hybrids as dual cholinesterase inhibitors for the treatment of Alzheimer's disease

N Sharon, VG Ugale, P Padmaja, D Lokwani… - Molecular Diversity, 2025 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease affecting mental ability and
neurocognitive functions. Cholinesterase enzymes affect concentration of acetylcholine in …

NMDA Receptor Antagonists: Emerging Insights into Molecular Mechanisms and Clinical Applications in Neurological Disorders

AO Egunlusi, J Joubert - Pharmaceuticals, 2024 - mdpi.com
Neurodegenerative disorders (NDs) include a range of chronic conditions characterized by
progressive neuronal loss, leading to cognitive, motor, and behavioral impairments …

[HTML][HTML] Analysis of skeletal diversity of multi-target directed ligands (MTDLs) targeting Alzheimer's disease

U Azam, MM Naseer, C Rochais - European Journal of Medicinal Chemistry, 2025 - Elsevier
Alzheimer's disease (AD) remains a significant healthcare challenge, necessitating
innovative therapeutic approaches to address its complex and multifactorial nature …

Tangeretin confers neuroprotection, cognitive and memory enhancement in global cerebral ischemia in rats

N Alla, S Palatheeya, SR Challa, R Kakarla - 3 Biotech, 2024 - Springer
Global cerebral ischemia is commonly associated with neurological deficits, including
cognitive and memory impairments. The present study aims to investigate the …

Asymmetric aza-Henry reaction toward trifluoromethyl β-nitroamines and biological investigation of their adamantane-type derivatives

Y Ren, M Du, Z Peng, C Zheng, G Zhao - Frontiers in Chemistry, 2024 - frontiersin.org
Amino acid-derived quaternary ammonium salts were successfully applied in the
asymmetric aza-Henry reaction of nitromethane to N-Boc trifluoromethyl ketimines. α …