The purpose of this study is to determine if amino acid neurotransmitters such as gamma-
aminobutyric acid (GABA), taurine, glutamate (Glu), and aspartate (Asp) can scavenge …

Introduction Epilepsy is a most common neurological disorder that has negative effects on
cognition. In the present study, we investigated the protective effect of Nigella sativa (NS) …

The gene kcnma1 encodes the α-subunit of high-conductance calcium-and voltage-
dependent K+ (BK) potassium channel. With the development of generation gene …

The effects of ethanol on the development of pentylenetetrazol (PTZ)-kindling as well as on
fully PTZ-kindled convulsions in rats were investigated. Ethanol (0.5, 1.0 and 1.5 g/kg ip) …

Experimental models of epilepsy, including pentylenetetrazol (PTZ) chemical kindling, are
very important in studying the pathophysiology of epilepsy. The aim of the present study was …

Abstract “Kindling” is a phenomenon of epileptogenesis, which has been widely used as an
experimental model of temporal lobe epilepsy. At the present work we investigated the …

Withdrawal from the endogenous steroid progesterone (P) after chronic administration
increases anxiety and seizure susceptibility via declining levels of its potent GABA …

Activity‐dependent synaptic plasticity has been thought to be a cellular basis of memory and
learning. The late phase of long‐term potentiation (L‐LTP), distinct from the early phase …

Background and purpose: The sodium channel is a primary target for treating central
nervous system disorders such as epilepsy. In this study the anticonvulsant effect of BmK …

In the present communication, the dynamic release of amino acid (AA) transmitters induced
by valproate (VPA) in pentylenetetrazol (PTZ)-kindled freely moving rats hippocampus has …