Conditional gene expression has greatly facilitated the examination of the functions of
particular gene products. Using the Cre/lox P switching expression system, we plan to …

MHC-class-I-presented peptides are predominantly generated by the proteasome system.
IFN-γ strongly influences the processing efficiency by inducing immunoproteasome …

The ability of killer T cells carrying the CD8 antigen to detect tumours or intracellular
pathogens requires an extensive display of antigenic peptides by major histocompatibility …

Precursors to major histocompatibility complex (MHC) class I–presented peptides with extra
NH2-terminal residues can be efficiently trimmed to mature epitopes in the endoplasmic …

The generation of many HLA class I peptides entails a final trimming step in the endoplasmic
reticulum that, in humans, is accomplished by two'candidate'aminopeptidases. We show …

Abstract Endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) appears to be specialized
to produce peptides presented on class I major histocompatibility complex molecules. We …

Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an IFN-γ-induced aminopeptidase in
the endoplasmic reticulum that trims longer precursors to the antigenic peptides presented …

Antigenic peptides generated by the proteasome have to survive a peptidase-containing
environment for presentation by MHC class I molecules. We have visualized the fate and …

Peptides presented by major histocompatibility complex class I molecules are derived
mainly from cytosolic oligopeptides generated by proteasomes during the degradation of …

Heat-shock proteins chaperone antigenic peptides that are generated within cells. Such
chaperoning is a part of the endogenous pathway of antigen presentation by MHC class I …