Abnormal calcium handling in Duchenne muscular dystrophy: mechanisms and potential therapies
Duchenne muscular dystrophy (DMD) is an X-linked muscle-wasting disease caused by the
loss of dystrophin. DMD is associated with muscle degeneration, necrosis, inflammation …
loss of dystrophin. DMD is associated with muscle degeneration, necrosis, inflammation …
Duchenne muscular dystrophy: pathogenesis and promising therapies
M Chang, Y Cai, Z Gao, X Chen, B Liu, C Zhang… - Journal of …, 2023 - Springer
Duchenne muscular dystrophy (DMD) is a severe, progressive, muscle-wasting disease,
characterized by progressive deterioration of skeletal muscle that causes rapid loss of …
characterized by progressive deterioration of skeletal muscle that causes rapid loss of …
MYTHO is a novel regulator of skeletal muscle autophagy and integrity
JP Leduc-Gaudet, A Franco-Romero, M Cefis… - Nature …, 2023 - nature.com
Autophagy is a critical process in the regulation of muscle mass, function and integrity. The
molecular mechanisms regulating autophagy are complex and still partly understood. Here …
molecular mechanisms regulating autophagy are complex and still partly understood. Here …
Lineage tracing of nuclei in skeletal myofibers uncovers distinct transcripts and interplay between myonuclear populations
Multinucleated skeletal muscle cells need to acquire additional nuclei through fusion with
activated skeletal muscle stem cells when responding to both developmental and adaptive …
activated skeletal muscle stem cells when responding to both developmental and adaptive …
Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin‐deficient mice
A Farini, L Tripodi, C Villa, F Strati… - EMBO molecular …, 2023 - embopress.org
Duchenne muscular dystrophy (DMD) is a progressive severe muscle‐wasting disease
caused by mutations in DMD, encoding dystrophin, that leads to loss of muscle function with …
caused by mutations in DMD, encoding dystrophin, that leads to loss of muscle function with …
[HTML][HTML] NTRK1-mediated protection against manganese-induced neurotoxicity and cell apoptosis via IGF2 in SH-SY5Y cells
C Zhang, B Jiao, X Cao, W Zhang, S Yu… - Biomedicine & …, 2023 - Elsevier
Abstract Background Excessive manganese (Mn) exposure has been linked to neurotoxicity,
cognitive impairments. Neurotrophic Receptor Kinase 1 (NTRK1) encodes Tropomyosin …
cognitive impairments. Neurotrophic Receptor Kinase 1 (NTRK1) encodes Tropomyosin …
Porphyromonas gingivalis fuels colorectal cancer through CHI3L1-mediated iNKT cell-driven immune evasion
A Díaz-Basabe, G Lattanzi, F Perillo, C Amoroso… - Gut …, 2024 - Taylor & Francis
The interaction between the gut microbiota and invariant Natural Killer T (iNKT) cells plays a
pivotal role in colorectal cancer (CRC). The pathobiont Fusobacterium nucleatum influences …
pivotal role in colorectal cancer (CRC). The pathobiont Fusobacterium nucleatum influences …
Targeting the DP2 receptor alleviates muscle atrophy and diet‐induced obesity in mice through oxidative myofiber transition
H Ning, H Ren, Y Zhao, HF Yin, Z Gan… - Journal of Cachexia …, 2023 - Wiley Online Library
Background Mammalian skeletal muscles consist of two main fibre types: slow‐twitch (type I,
oxidative) and fast‐twitch (type IIa, fast oxidative; type IIb/IIx, fast glycolytic). Muscle fibre …
oxidative) and fast‐twitch (type IIa, fast oxidative; type IIb/IIx, fast glycolytic). Muscle fibre …
Role of insulin-like growth factor receptor 2 across muscle homeostasis: implications for treating muscular dystrophy
Y Torrente, P Bella, L Tripodi, C Villa, A Farini - Cells, 2020 - mdpi.com
The insulin-like growth factor 2 receptor (IGF2R) plays a major role in binding and regulating
the circulating and tissue levels of the mitogenic peptide insulin-like growth factor 2 (IGF2) …
the circulating and tissue levels of the mitogenic peptide insulin-like growth factor 2 (IGF2) …
CREG1 stimulates AMPK phosphorylation and glucose uptake in skeletal muscle cells
A Goto, Y Endo, H Yamashita - Biochemical and Biophysical Research …, 2023 - Elsevier
The cellular repressor of adenovirus early region 1A-stimulated gene 1 (CREG1) is a
secreted glycoprotein involved in cell differentiation and energy metabolism. It also binds to …
secreted glycoprotein involved in cell differentiation and energy metabolism. It also binds to …