Abnormal calcium handling in Duchenne muscular dystrophy: mechanisms and potential therapies

S Mareedu, ED Million, D Duan, GJ Babu - Frontiers in physiology, 2021 - frontiersin.org
Duchenne muscular dystrophy (DMD) is an X-linked muscle-wasting disease caused by the
loss of dystrophin. DMD is associated with muscle degeneration, necrosis, inflammation …

Duchenne muscular dystrophy: pathogenesis and promising therapies

M Chang, Y Cai, Z Gao, X Chen, B Liu, C Zhang… - Journal of …, 2023 - Springer
Duchenne muscular dystrophy (DMD) is a severe, progressive, muscle-wasting disease,
characterized by progressive deterioration of skeletal muscle that causes rapid loss of …

MYTHO is a novel regulator of skeletal muscle autophagy and integrity

JP Leduc-Gaudet, A Franco-Romero, M Cefis… - Nature …, 2023 - nature.com
Autophagy is a critical process in the regulation of muscle mass, function and integrity. The
molecular mechanisms regulating autophagy are complex and still partly understood. Here …

Lineage tracing of nuclei in skeletal myofibers uncovers distinct transcripts and interplay between myonuclear populations

C Sun, CO Swoboda, FM Morales, C Calvo… - Nature …, 2024 - nature.com
Multinucleated skeletal muscle cells need to acquire additional nuclei through fusion with
activated skeletal muscle stem cells when responding to both developmental and adaptive …

Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin‐deficient mice

A Farini, L Tripodi, C Villa, F Strati… - EMBO molecular …, 2023 - embopress.org
Duchenne muscular dystrophy (DMD) is a progressive severe muscle‐wasting disease
caused by mutations in DMD, encoding dystrophin, that leads to loss of muscle function with …

[HTML][HTML] NTRK1-mediated protection against manganese-induced neurotoxicity and cell apoptosis via IGF2 in SH-SY5Y cells

C Zhang, B Jiao, X Cao, W Zhang, S Yu… - Biomedicine & …, 2023 - Elsevier
Abstract Background Excessive manganese (Mn) exposure has been linked to neurotoxicity,
cognitive impairments. Neurotrophic Receptor Kinase 1 (NTRK1) encodes Tropomyosin …

Porphyromonas gingivalis fuels colorectal cancer through CHI3L1-mediated iNKT cell-driven immune evasion

A Díaz-Basabe, G Lattanzi, F Perillo, C Amoroso… - Gut …, 2024 - Taylor & Francis
The interaction between the gut microbiota and invariant Natural Killer T (iNKT) cells plays a
pivotal role in colorectal cancer (CRC). The pathobiont Fusobacterium nucleatum influences …

Targeting the DP2 receptor alleviates muscle atrophy and diet‐induced obesity in mice through oxidative myofiber transition

H Ning, H Ren, Y Zhao, HF Yin, Z Gan… - Journal of Cachexia …, 2023 - Wiley Online Library
Background Mammalian skeletal muscles consist of two main fibre types: slow‐twitch (type I,
oxidative) and fast‐twitch (type IIa, fast oxidative; type IIb/IIx, fast glycolytic). Muscle fibre …

Role of insulin-like growth factor receptor 2 across muscle homeostasis: implications for treating muscular dystrophy

Y Torrente, P Bella, L Tripodi, C Villa, A Farini - Cells, 2020 - mdpi.com
The insulin-like growth factor 2 receptor (IGF2R) plays a major role in binding and regulating
the circulating and tissue levels of the mitogenic peptide insulin-like growth factor 2 (IGF2) …

CREG1 stimulates AMPK phosphorylation and glucose uptake in skeletal muscle cells

A Goto, Y Endo, H Yamashita - Biochemical and Biophysical Research …, 2023 - Elsevier
The cellular repressor of adenovirus early region 1A-stimulated gene 1 (CREG1) is a
secreted glycoprotein involved in cell differentiation and energy metabolism. It also binds to …