Chemically modified biomacromolecules─ ie, proteins, nucleic acids, glycans, and lipids─
have become crucial tools in chemical biology. They are extensively used not only to …

There has been a significant push in recent years to deploy fundamental knowledge and
methods of photochemistry toward biological ends. Photoreactive groups have enabled …

Photochemical tools have revolutionized the landscape of biomedicine, enabling the
exploration of nature in a noninvasively remote-controlled manner. Among them, especially …

A novel photocaged PI3K inhibitor 2 was designed and synthesized by introducing a
cascade photocaging group to block its key interaction with the kinase. Upon UV light …

Photocaged proteolysis-targeting chimeras (PROTACs), which employ light as a stimulus to
control protein degradation, have recently garnered considerable attention as both powerful …

A series of dipolar-type terphenyl derivatives 1–3 featuring an electron donor (p-NMe2C6H4
group) and acceptor (p-NO2C6H4 group) unit was synthesized and their photophysical …

Protein and peptide prenylation is an essential biological process involved in many signal
transduction pathways. In its most prevalent form, prenylation involves three enzymatic …

Photoirradiation provides a convenient and biocompatible approach for spatiotemporal
modulation of biological systems with photoresponsive components. The construction of …

The ability to selectively deliver bioactive molecules with high spatial and temporal
resolution has applications in many areas of chemical biology and drug delivery. Using …

The first total syntheses of (±)-melicolone A and (±)-melicolone B was accomplished in a
combined overall yield of 12.3% and a mere 9 steps from commercially available reagents …