RhoA signaling in neurodegenerative diseases
Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in
regulating multiple signal transduction pathways that influence a diverse range of cellular …
regulating multiple signal transduction pathways that influence a diverse range of cellular …
Altered cholesterol homeostasis in Huntington's disease
Huntington's disease (HD) is an autosomal dominant genetic disorder caused by an
expansion of the CAG repeat in the first exon of Huntingtin's gene. The associated …
expansion of the CAG repeat in the first exon of Huntingtin's gene. The associated …
[HTML][HTML] Vildagliptin attenuates Huntington's disease through activation of GLP-1 receptor/PI3K/Akt/BDNF pathway in 3-nitropropionic acid rat model
Vildagliptin (Vilda), a dipeptidyl peptidase-4 (DPP-4) inhibitor, has been highlighted as a
promising therapeutic agent for neurodegenerative diseases as Alzheimer's and Parkinson's …
promising therapeutic agent for neurodegenerative diseases as Alzheimer's and Parkinson's …
Advantages of Rho-associated kinases and their inhibitor fasudil for the treatment of neurodegenerative diseases
Q Wang, LJ Song, ZB Ding, Z Chai, JZ Yu… - Neural regeneration …, 2022 - journals.lww.com
Ras homolog (Rho)-associated kinases (ROCKs) belong to the serine-threonine kinase
family, which plays a pivotal role in regulating the damage, survival, axon guidance, and …
family, which plays a pivotal role in regulating the damage, survival, axon guidance, and …
New insights into the role of berberine against 3-nitropropionic acid-induced striatal neurotoxicity: Possible role of BDNF–TrkB–PI3K/Akt and NF-κB signaling
New insights into the role of berberine against 3-nitropropionic acid-induced striatal
neurotoxicity: Possible role of BDNF–TrkB–PI3K/Akt and NF-κB signaling - ScienceDirect …
neurotoxicity: Possible role of BDNF–TrkB–PI3K/Akt and NF-κB signaling - ScienceDirect …
Rutin and selenium co-administration reverse 3-nitropropionic acid-induced neurochemical and molecular impairments in a mouse model of Huntington's disease
Systemic administration of 3-nitropropionic acid (3-NPA) is commonly used to induce
Huntington's disease (HD)-like symptoms in experimental animals. Here, the potential …
Huntington's disease (HD)-like symptoms in experimental animals. Here, the potential …
Pharmacological modulators of small GTPases of rho family in neurodegenerative diseases
W Guiler, A Koehler, C Boykin, Q Lu - Frontiers in Cellular …, 2021 - frontiersin.org
Classical Rho GTPases, including RhoA, Rac1, and Cdc42, are members of the Ras small
GTPase superfamily and play essential roles in a variety of cellular functions. Rho GTPase …
GTPase superfamily and play essential roles in a variety of cellular functions. Rho GTPase …
Activated ROCK/Akt/eNOS and ET-1/ERK pathways in 5-fluorouracil-induced cardiotoxicity: modulation by simvastatin
Fluorouracil (5-FU) is used in the treatment of different solid tumors; however, its use is
associated with rare, but serious cardiotoxicity. Nevertheless, the involvement of ROCK/NF …
associated with rare, but serious cardiotoxicity. Nevertheless, the involvement of ROCK/NF …
An overview of the pathophysiological mechanisms of 3-nitropropionic acid (3-NPA) as a neurotoxin in a huntington's disease model and its relevance to drug …
S Upadhayay, NG Yedke, V Rahi, S Singh… - Neurochemical …, 2023 - Springer
Animal models are used to better understand the various mechanisms involved in the
pathogenesis of diseases and explore potential pathways that will aid in discovering …
pathogenesis of diseases and explore potential pathways that will aid in discovering …
Neurodegenerative disease associated pathways in the brains of triple transgenic Alzheimer's model mice are reversed following two weeks of peripheral …
The pan Rho-associated coiled-coil-containing protein kinase (ROCK) inhibitor fasudil acts
as a vasodilator and has been used as a medication for post-cerebral stroke for the past 29 …
as a vasodilator and has been used as a medication for post-cerebral stroke for the past 29 …