Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular
composition under physiological and pathophysiological conditions. The emergence of …

Comprehensively charting the biologically causal circuits that govern the phenotypic space
of human cells has often been viewed as an insurmountable challenge. However, in the last …

Macrophages are heterogeneous and play critical roles in development and disease, but
their diversity, function, and specification remain inadequately understood during human …

Differential expression analysis of single-cell RNA sequencing (scRNA-seq) data is central
for characterizing how experimental factors affect the distribution of gene expression …

It is now well established that Th17 lymphocytes associate with myriad immune-mediated
inflammatory diseases. Over the past one and a half decades, a subset of Th17 lymphocytes …

The effects of genetic variation on complex traits act mainly through changes in gene
regulation. Although many genetic variants have been linked to target genes in cis, the trans …

Key message This study provided important insights into the genetic architecture of
variations in A. thaliana leaf ionome in a cell-type-specific manner. Abstract The functional …

Molecular quantitative trait loci (QTLs) allow us to understand the biology captured in
genome-wide association studies (GWASs). The placenta regulates fetal development and …

Multiple lines of evidence indicate that ankylosing spondylitis (AS) is a lymphocyte-driven
disease. However, which lymphocyte populations are critical in AS pathogenesis is not …

The increase in publicly available human single-cell datasets, encompassing millions of
cells from many donors, has significantly enhanced our understanding of complex biological …