Diabetes mellitus occurrence has been associated to the modification of the physiological
levels of glucose and is often accompanied by several long-term complications, namely …

Aldose reductase [ALR2; EC 1.1. 1.21], a key enzyme of polyol pathway, catalyzes NADPH-
dependent reduction of glucose to sorbitol (Sorbitol pathway), and an excessive …

Abstract A series of 4-(thiazol-2-ylamino)-benzenesulfonamides was synthesized and
screened for their carbonic anhydrase (CA, EC 4.2. 1.1) inhibitory and cytotoxic activity on …

Four series of sulfonamides incorporating chromone moieties were synthesized and
assessed for their cytotoxic activity against MCF-7 and A-549 cell lines, considering the fact …

This paper describes for the first time the synthesis and microbiological assessment of some
new β-lactam derivatives containing a 1, 8-naphthalimide functional group. These …

Two closely related diaryl acylsulfonamides were recently reported as potent antitumor
agents against a broad spectrum of human tumor xenografts (colon, lung, breast, ovary, and …

A series of new indole derivatives 1–18 was synthesized and tested for their cytotoxic activity
on a panel of 60 tumor cell lines. Additionally, molecular docking was carried out to study …

A new series of thiazolopyrane 5a–d, 11–13 and thiazolopyranopyrimidine 6–10, 7b, 8b,
and 14 derivatives bearing a sulfonamide moiety were designed and synthesized. The …

New thiazolo [4, 5-d] pyrimidines 4a, b, thioxopropanoic acid ethyl ester 7 and 4-
oxothiazolidine benzenesulfonamides 9a-h were designed and synthesized. The molecular …

Two series of novel 4-chloro-2-(benzylthio)-5-(1, 3, 4-oxadiazol-2-yl) benzenesulfonamides
and their N-aroyl derivatives have been synthesized and evaluated for in vitro anticancer …