Cancer stem cells (CSCs) show a self-renewal capacity and differentiation potential that
contribute to tumor progression and therapy resistance. However, the underlying processes …

Despite the abundant ongoing research efforts, cancer remains one of the most challenging
diseases to treat globally. Due to the heterogenous nature of cancer, one of the major …

Most patients with advanced triple-negative breast cancer (TNBC) develop drug resistance.
MYC and MCL1 are frequently co-amplified in drug-resistant TNBC after neoadjuvant …

Abstract CD44/CD24 and ALDH1 are widely used cancer stem cell (CSC) markers in breast
cancer. However, their expression is not always consistent even in the same subtype of …

Highlights•Physical cues from the tumor microenvironment strongly affect cancer cell
behavior.•Novel techniques increasingly help to capture those cues in vitro.•Mechanisms for …

Distant metastasis accounts for the vast majority of deaths in patients with cancer. Breast
cancer exhibits a distinct metastatic pattern commonly involving bone, liver, lung, and brain …

Abstract Development of therapeutic resistance and metastasis is a major challenge with
current breast cancer (BC) therapy. Mounting evidence suggests that a subpopulation of …

The insufficient and unspecific target of traditional therapeutic approaches in cancer
treatment often leads to therapy resistance and cancer recurrence. Over the past decades …

Over the last decades, the cancer survival rate has increased due to personalized therapies,
the discovery of targeted therapeutics and novel biological agents, and the application of …

Cancer stem cell population is a subset of cells capable of dictating invasion, metastasis,
heterogeneity, and therapeutic resistance in tumours. Eradication of this rare population is a …