Urinary tract infections: pathogenesis, host susceptibility and emerging therapeutics

MR Timm, SK Russell, SJ Hultgren - Nature Reviews Microbiology, 2024 - nature.com
Urinary tract infections (UTIs), which include any infection of the urethra, bladder or kidneys,
account for an estimated 400 million infections and billions of dollars in health-care …

[HTML][HTML] The intracellular life of Acinetobacter baumannii

A Maure, E Robino, C Van der Henst - Trends in Microbiology, 2023 - cell.com
Acinetobacter baumannii is a Gram-negative opportunistic bacterium responsible for
nosocomial and community-acquired infections. This pathogen is globally disseminated and …

Contribution of the patient microbiome to surgical site infection and antibiotic prophylaxis failure in spine surgery

DR Long, C Bryson-Cahn, A Waalkes… - Science Translational …, 2024 - science.org
Despite modern antiseptic techniques, surgical site infection (SSI) remains a leading
complication of surgery. However, the origins of SSI and the high rates of antimicrobial …

Atypical B Cells Promote Cancer Progression and Poor Response to Bacillus Calmette-Guérin in Non–Muscle Invasive Bladder Cancer

P Yolmo, S Rahimi, S Chenard, G Conseil… - Cancer immunology …, 2024 - aacrjournals.org
Abstract Poor response to Bacillus Calmette-Guérin (BCG) immunotherapy remains a major
barrier in the management of patients with non–muscle invasive bladder cancer (NMIBC) …

The multifaceted genus Acinetobacter: from infection to bioremediation

U Dahal, K Paul, S Gupta - Journal of Applied Microbiology, 2023 - academic.oup.com
Acinetobacter is a vast bacterial genus comprising of numerous species with variable
characteristics. The enigma associated with clinical strains that have been implicated in …

Carbapenem-resistant Acinetobacter baumannii (CRAB): metabolic adaptation and transcriptional response to human urine (HU)

J Escalante, M Hamza, B Nishimura, M Melecio… - Scientific Reports, 2024 - nature.com
Carbapenem-resistant Acinetobacter baumannii (CRAB) is a major human pathogen and a
research priority for develo** new antimicrobial agents. CRAB is a causative agent of a …

Replicative Acinetobacter baumannii strains interfere with phagosomal maturation by modulating the vacuolar pH

JS Distel, G Di Venanzio, JJ Mackel, DA Rosen… - PLoS …, 2023 - journals.plos.org
Bacterial pneumonia is a common infection of the lower respiratory tract that can afflict
patients of all ages. Multidrug-resistant strains of Acinetobacter baumannii are increasingly …

Nur77 protects the bladder urothelium from intracellular bacterial infection

CA Collins, C Waller, E Batourina, L Kumar… - Nature …, 2024 - nature.com
Intracellular infections by Gram-negative bacteria are a significant global health threat. The
nuclear receptor Nur77 (also called TR3, NGFI-B, or NR4A1) was recently shown to sense …

Azithromycin inhibits the intracellular persistence of Acinetobacter baumannii by inducing host cell autophagy in human bronchial epithelial cells

B Weng, Y Li, W Feng, P Yao, Y Wang, Q Wang… - Microbial …, 2025 - Elsevier
The invasion of host cells by bacteria, leading to intracellular infections, is a major cause of
infection recurrence. Drug-resistant Acinetobacter baumannii (A. baumannii) is one of the …

Mucus-inspired lubricative antibacterial coating to reduce airway complications in an intubation cynomolgus monkey model

JY Wang, YQ Wei, QN Wang, ZG Wang, R Hong… - Chinese Chemical …, 2024 - Elsevier
Endotracheal intubation-related complications are common in clinical, and there are
currently no effective strategies to address these matters. Inspired by the biological …