The ferritins: molecular properties, iron storage function and cellular regulation

PM Harrison, P Arosio - Biochimica et biophysica acta (BBA)-bioenergetics, 1996‏ - Elsevier
The iron storage protein, ferritin, plays a key role in iron metabolism. Its ability to sequester
the element gives ferritin the dual functions of iron detoxification and iron reserve. The …

Chemistry and biology of eukaryotic iron metabolism

P Aisen, C Enns, M Wessling-Resnick - The international journal of …, 2001‏ - Elsevier
With rare exceptions, virtually all studied organisms from Archaea to man are dependent on
iron for survival. Despite the ubiquitous distribution and abundance of iron in the biosphere …

The transferrin receptor: role in health and disease

P Ponka, CN Lok - The international journal of biochemistry & cell biology, 1999‏ - Elsevier
The transferrin receptor is a membrane glycoprotein whose only clearly defined function is to
mediate cellular uptake of iron from a plasma glycoprotein, transferrin. Iron uptake from …

Regulation of brain iron and copper homeostasis by brain barrier systems: implication in neurodegenerative diseases

W Zheng, AD Monnot - Pharmacology & therapeutics, 2012‏ - Elsevier
Iron (Fe) and copper (Cu) are essential to neuronal function; excess or deficiency of either is
known to underlie the pathoetiology of several commonly known neurodegenerative …

Tissue-specific regulation of iron metabolism and heme synthesis: distinct control mechanisms in erythroid cells

P Ponka - Blood, The Journal of the American Society of …, 1997‏ - ashpublications.org
Thrombopoietin (TPO) is the primary hematopoietic growth let counts, the cells of the
proximal convoluted tubules of factor involved in the regulation of platelet production. Al- the …

Iron overload and its association with cancer risk in humans: evidence for iron as a carcinogenic metal

X Huang - … Research/Fundamental and Molecular Mechanisms of …, 2003‏ - Elsevier
Unlike arsenic, chromium, or nickel, the carcinogenicity of iron is still under debate. In this
review, evidence for iron as a carcinogenic metal was summarized from epidemiological …

Regulation of iron acquisition and storage: consequences for iron-linked disorders

I De Domenico, D McVey Ward, J Kaplan - Nature reviews Molecular …, 2008‏ - nature.com
Mammalian iron homeostasis must be meticulously regulated so that this essential element
is available for use, but at the same time prevented from promoting the formation of toxic …

DMT1: a mammalian transporter for multiple metals

MD Garrick, KG Dolan, C Horbinski, AJ Ghio, D Higgins… - Biometals, 2003‏ - Springer
DMT1 has four names, transports as many as eight metals, may have four or more isoforms
and carries out its transport for multiple purposes. This review is a start at sorting out these …

Crystal structure of the ectodomain of human transferrin receptor

CM Lawrence, S Ray, M Babyonyshev, R Galluser… - Science, 1999‏ - science.org
The transferrin receptor (TfR) undergoes multiple rounds of clathrin-mediated endocytosis
and reemergence at the cell surface, importing iron-loaded transferrin (Tf) and recycling …

Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor

MJ Bennett, JA Lebrón, PJ Bjorkman - Nature, 2000‏ - nature.com
HFE is related to major histocompatibility complex (MHC) class I proteins and is mutated in
the iron-overload disease hereditary haemochromatosis. HFE binds to the transferrin …