Urinary tract infections: epidemiology, mechanisms of infection and treatment options

AL Flores-Mireles, JN Walker, M Caparon… - Nature reviews …, 2015 - nature.com
Urinary tract infections (UTIs) are a severe public health problem and are caused by a range
of pathogens, but most commonly by Escherichia coli, Klebsiella pneumoniae, Proteus …

Urinary tract infections: microbial pathogenesis, host–pathogen interactions and new treatment strategies

RD Klein, SJ Hultgren - Nature Reviews Microbiology, 2020 - nature.com
Urinary tract infections (UTIs) are common, recurrent infections that can be mild to life-
threatening. The continued emergence of antibiotic resistance, together with our increasing …

UroPathogenic Escherichia coli (UPEC) Infections: Virulence Factors, Bladder Responses, Antibiotic, and Non-antibiotic Antimicrobial Strategies

ME Terlizzi, G Gribaudo, ME Maffei - Frontiers in microbiology, 2017 - frontiersin.org
Urinary tract infections (UTIs) are one of the most common pathological conditions in both
community and hospital settings. It has been estimated that about 150 million people …

Biofilm infections, their resilience to therapy and innovative treatment strategies

U Römling, C Balsalobre - Journal of internal medicine, 2012 - Wiley Online Library
Biofilm formation of microorganisms causes persistent tissue and foreign body infections
resistant to treatment with antimicrobial agents. Up to 80% of human bacterial infections are …

Urinary tract infection: pathogenesis and outlook

LK McLellan, DA Hunstad - Trends in molecular medicine, 2016 - cell.com
The clinical syndromes comprising urinary tract infection (UTI) continue to exert significant
impact on millions of patients worldwide, most of whom are otherwise healthy women …

From in vitro to in vivo Models of Bacterial Biofilm-Related Infections

D Lebeaux, A Chauhan, O Rendueles, C Beloin - Pathogens, 2013 - mdpi.com
The influence of microorganisms growing as sessile communities in a large number of
human infections has been extensively studied and recognized for 30–40 years, therefore …

The emerging threat of multidrug-resistant Gram-negative bacteria in urology

HM Zowawi, PNA Harris, MJ Roberts… - Nature Reviews …, 2015 - nature.com
Antibiotic resistance in Gram-negative uropathogens is a major global concern. Worldwide,
the prevalence of Enterobacteriaceae that produce extended-spectrum β-lactamase or …

Urinary Tract Infections Caused by Uropathogenic Escherichia coli: Mechanisms of Infection and Treatment Options

Y Zhou, Z Zhou, L Zheng, Z Gong, Y Li, Y **… - International journal of …, 2023 - mdpi.com
Urinary tract infections (UTIs) are common bacterial infections that represent a severe public
health problem. They are often caused by Escherichia coli (E. coli), Klebsiella pneumoniae …

A comprehensive guide to pilus biogenesis in Gram-negative bacteria

MK Hospenthal, TRD Costa, G Waksman - Nature reviews microbiology, 2017 - nature.com
Pili are crucial virulence factors for many Gram-negative pathogens. These surface
structures provide bacteria with a link to their external environments by enabling them to …

Microbial biofilm: A matter of grave concern for human health and food industry

MA Rather, K Gupta, P Bardhan… - Journal of Basic …, 2021 - Wiley Online Library
Pathogenic microorganisms have adapted different strategies during the course of time to
invade host defense mechanisms and overcome the effect of potent antibiotics. The …