Obesity and hypertension, which often coexist, are major risk factors for heart failure and are
characterized by chronic, low-grade inflammation, which promotes adverse cardiac …

Wound healing requires cooperation between different cell types, among which
macrophages play a central role. In particular, inflammatory macrophages are engaged in …

The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …

Ischemia-reperfusion (IR) injury is central to the pathology of major cardiovascular diseases,
such as stroke and myocardial infarction. IR injury is mediated by several factors including …

Hypoxia is a hallmark of solid tumors that promotes cell growth, survival, and metastasis and
confers resistance to chemo and radiotherapies. Hypoxic responses are largely mediated by …

NRF2 (Nuclear factor E2 p45‐related factor 2) is a stress responsive transcription factor
lending cells resilience against oxidative, xenobiotic, and also nutrient or proteotoxic insults …

The NFE2L2 gene encodes the transcription factor Nrf2 best known for regulating the
expression of antioxidant and detoxification genes. Gene knockout approaches have …

Ischaemia-reperfusion injury occurs when the blood supply to an organ is disrupted and
then restored, and underlies many disorders, notably heart attack and stroke. While …

Ischemia-reperfusion (IR) injury occurs when blood supply to an organ is disrupted—
ischemia—and then restored—reperfusion—leading to a burst of reactive oxygen species …

The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …