[HTML][HTML] lncRNA NEAT1: Key player in neurodegenerative diseases

K Li, Z Wang - Ageing Research Reviews, 2023 - Elsevier
Neurodegenerative diseases are the most common causes of disability worldwide. Given
their high prevalence, devastating symptoms, and lack of definitive diagnostic tests, there is …

Functional roles and networks of non-coding RNAs in the pathogenesis of neurodegenerative diseases

YY Wu, HC Kuo - Journal of Biomedical Science, 2020 - Springer
Recent transcriptome analyses have revealed that noncoding RNAs (ncRNAs) are broadly
expressed in mammalian cells and abundant in the CNS, with tissue and cell type-specific …

MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's disease

S Balusu, K Horré, N Thrupp, K Craessaerts, A Snellinx… - Science, 2023 - science.org
Neuronal cell loss is a defining feature of Alzheimer's disease (AD), but the underlying
mechanisms remain unclear. We xenografted human or mouse neurons into the brain of a …

Long non‐coding RNAs in development and disease: conservation to mechanisms

I Tsagakis, K Douka, I Birds… - The Journal of …, 2020 - Wiley Online Library
Our genomes contain the blueprint of what makes us human and many indications as to why
we develop disease. Until the last 10 years, most studies had focussed on protein‐coding …

Paraspeckle nuclear condensates: Global sensors of cell stress?

F McCluggage, AH Fox - Bioessays, 2021 - Wiley Online Library
Paraspeckles are nuclear condensates, or membranelees organelles, that are built on the
long noncoding RNA, NEAT1, and have been linked to many diseases. Although originally …

Roles of ncRNAs as ceRNAs in Gastric Cancer

J Ye, J Li, P Zhao - Genes, 2021 - mdpi.com
Although ignored in the past, with the recent deepening of research, significant progress has
been made in the field of non-coding RNAs (ncRNAs). Accumulating evidence has revealed …

[PDF][PDF] Long noncoding RNA NEAT1 aggravates Aβ-induced neuronal damage by targeting miR-107 in Alzheimer's disease

S Ke, Z Yang, F Yang, X Wang, J Tan… - Yonsei medical …, 2019 - synapse.koreamed.org
Purpose Alzheimer's disease (AD) is the most common neurodegenerative disease, with a
rising prevalence worldwide. Long noncoding RNAs (lncRNAs) have been found to play …

[HTML][HTML] NEAT1 and paraspeckles in neurodegenerative diseases: A missing lnc found?

H An, NG Williams, TA Shelkovnikova - Non-coding RNA research, 2018 - Elsevier
Neurodegenerative diseases are among the most common causes of disability worldwide.
Although neurodegenerative diseases are heterogeneous in both their clinical features and …

[HTML][HTML] Long noncoding RNA Meg3 mediates ferroptosis induced by oxygen and glucose deprivation combined with hyperglycemia in rat brain microvascular …

C Chen, Y Huang, P **a, F Zhang, L Li… - European journal of …, 2021 - ncbi.nlm.nih.gov
Individuals with diabetes are exposed to a higher risk of perioperative stroke than non-
diabetics mainly due to persistent hyperglycemia. LncRNA Meg3 has been considered as …

Molecular landscape of long noncoding RNAs in brain disorders

S Yang, KH Lim, SH Kim, JY Joo - Molecular psychiatry, 2021 - nature.com
According to current paradigms, various risk factors, such as genetic mutations, oxidative
stress, neural network dysfunction, and abnormal protein degradation, contribute to the …