RAF-MEK-ERK pathway in cancer evolution and treatment

R Ullah, Q Yin, AH Snell, L Wan - Seminars in cancer biology, 2022 - Elsevier
Abstract The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …

Cisplatin based therapy: the role of the mitogen activated protein kinase signaling pathway

IW Achkar, N Abdulrahman, H Al-Sulaiti… - Journal of translational …, 2018 - Springer
Cisplatin is a widely used chemotherapeutic agent for treatment of various cancers.
However, treatment with cisplatin is associated with drug resistance and several adverse …

[HTML][HTML] The PLAG1-GDH1 axis promotes anoikis resistance and tumor metastasis through CamKK2-AMPK signaling in LKB1-deficient lung cancer

L **, J Chun, C Pan, A Kumar, G Zhang, Y Ha, D Li… - Molecular cell, 2018 - cell.com
Loss of LKB1 is associated with increased metastasis and poor prognosis in lung cancer,
but the development of targeted agents is in its infancy. Here we report that a glutaminolytic …

Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles

IM Serafimova, MA Pufall, S Krishnan, K Duda… - Nature chemical …, 2012 - nature.com
Targeting noncatalytic cysteine residues with irreversible acrylamide-based inhibitors is a
powerful approach for enhancing pharmacological potency and selectivity. Nevertheless …

Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis

L **, J Chun, C Pan, GN Alesi, D Li, KR Magliocca… - Oncogene, 2017 - nature.com
Metastases remain the major cause of death from cancer. Recent molecular advances have
highlighted the importance of metabolic alterations in cancer cells, including the Warburg …

Covalent docking of large libraries for the discovery of chemical probes

N London, RM Miller, JJ Irwin, O Eidam, L Gibold… - Biophysical …, 2014 - cell.com
Chemical probes that form a covalent bond with a protein target often show enhanced
selectivity, potency, and utility for biological studies. Despite these advantages, protein …

MAST1 drives cisplatin resistance in human cancers by rewiring cRaf-independent MEK activation

L **, J Chun, C Pan, D Li, R Lin, GN Alesi, X Wang… - Cancer cell, 2018 - cell.com
Platinum-based chemotherapeutics represent a mainstay of cancer therapy, but resistance
limits their curative potential. Through a kinome RNAi screen, we identified microtubule …

[HTML][HTML] A Direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration

T Wuestefeld, M Pesic, R Rudalska, D Dauch… - Cell, 2013 - cell.com
The liver harbors a distinct capacity for endogenous regeneration; however, liver
regeneration is often impaired in disease and therefore insufficient to compensate for the …

RSK isoforms in cancer cell invasion and metastasis

FJ Sulzmaier, JW Ramos - Cancer research, 2013 - AACR
Metastasis, the spreading of cancer cells from a primary tumor to secondary sites throughout
the body, is the primary cause of death for patients with cancer. New therapies that prevent …

Ribosomal S6 protein kinase 4 promotes radioresistance in esophageal squamous cell carcinoma

MY Li, LN Fan, DH Han, Z Yu, J Ma… - The Journal of …, 2020 - Am Soc Clin Investig
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancers and is
highly resistant to current treatments. ESCC harbors a subpopulation of cells exhibiting …