RAF-MEK-ERK pathway in cancer evolution and treatment
Abstract The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …
Cisplatin based therapy: the role of the mitogen activated protein kinase signaling pathway
IW Achkar, N Abdulrahman, H Al-Sulaiti… - Journal of translational …, 2018 - Springer
Cisplatin is a widely used chemotherapeutic agent for treatment of various cancers.
However, treatment with cisplatin is associated with drug resistance and several adverse …
However, treatment with cisplatin is associated with drug resistance and several adverse …
[HTML][HTML] The PLAG1-GDH1 axis promotes anoikis resistance and tumor metastasis through CamKK2-AMPK signaling in LKB1-deficient lung cancer
Loss of LKB1 is associated with increased metastasis and poor prognosis in lung cancer,
but the development of targeted agents is in its infancy. Here we report that a glutaminolytic …
but the development of targeted agents is in its infancy. Here we report that a glutaminolytic …
Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles
Targeting noncatalytic cysteine residues with irreversible acrylamide-based inhibitors is a
powerful approach for enhancing pharmacological potency and selectivity. Nevertheless …
powerful approach for enhancing pharmacological potency and selectivity. Nevertheless …
Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis
Metastases remain the major cause of death from cancer. Recent molecular advances have
highlighted the importance of metabolic alterations in cancer cells, including the Warburg …
highlighted the importance of metabolic alterations in cancer cells, including the Warburg …
Covalent docking of large libraries for the discovery of chemical probes
Chemical probes that form a covalent bond with a protein target often show enhanced
selectivity, potency, and utility for biological studies. Despite these advantages, protein …
selectivity, potency, and utility for biological studies. Despite these advantages, protein …
MAST1 drives cisplatin resistance in human cancers by rewiring cRaf-independent MEK activation
Platinum-based chemotherapeutics represent a mainstay of cancer therapy, but resistance
limits their curative potential. Through a kinome RNAi screen, we identified microtubule …
limits their curative potential. Through a kinome RNAi screen, we identified microtubule …
[HTML][HTML] A Direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration
The liver harbors a distinct capacity for endogenous regeneration; however, liver
regeneration is often impaired in disease and therefore insufficient to compensate for the …
regeneration is often impaired in disease and therefore insufficient to compensate for the …
RSK isoforms in cancer cell invasion and metastasis
FJ Sulzmaier, JW Ramos - Cancer research, 2013 - AACR
Metastasis, the spreading of cancer cells from a primary tumor to secondary sites throughout
the body, is the primary cause of death for patients with cancer. New therapies that prevent …
the body, is the primary cause of death for patients with cancer. New therapies that prevent …
Ribosomal S6 protein kinase 4 promotes radioresistance in esophageal squamous cell carcinoma
MY Li, LN Fan, DH Han, Z Yu, J Ma… - The Journal of …, 2020 - Am Soc Clin Investig
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancers and is
highly resistant to current treatments. ESCC harbors a subpopulation of cells exhibiting …
highly resistant to current treatments. ESCC harbors a subpopulation of cells exhibiting …