Abstract The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …

Cisplatin is a widely used chemotherapeutic agent for treatment of various cancers.
However, treatment with cisplatin is associated with drug resistance and several adverse …

Loss of LKB1 is associated with increased metastasis and poor prognosis in lung cancer,
but the development of targeted agents is in its infancy. Here we report that a glutaminolytic …

Targeting noncatalytic cysteine residues with irreversible acrylamide-based inhibitors is a
powerful approach for enhancing pharmacological potency and selectivity. Nevertheless …

Metastases remain the major cause of death from cancer. Recent molecular advances have
highlighted the importance of metabolic alterations in cancer cells, including the Warburg …

Chemical probes that form a covalent bond with a protein target often show enhanced
selectivity, potency, and utility for biological studies. Despite these advantages, protein …

Platinum-based chemotherapeutics represent a mainstay of cancer therapy, but resistance
limits their curative potential. Through a kinome RNAi screen, we identified microtubule …

The liver harbors a distinct capacity for endogenous regeneration; however, liver
regeneration is often impaired in disease and therefore insufficient to compensate for the …

Metastasis, the spreading of cancer cells from a primary tumor to secondary sites throughout
the body, is the primary cause of death for patients with cancer. New therapies that prevent …

Vimang is a standardized extract derived from Mango bark (Mangifera Indica L.), commonly
used as anti-inflammatory phytomedicine, which has recently been used to complement …